BRCA2

 
Hsap
MPI............GS........................KERPTFFEI
Ptro
MPI............GS........................KERPTFFEI
Mmul
MSI............GS........................KERPTFFEI
Rnor
MTV............EY........................KRRPTFWEI
Cfam
MPV............GC........................KERPTFFEI
Btau
MPI............GC........................KERPTFFDI
Mdom
MSA............GY........................QGKTTFFEV
Ggal
MAY............KS........................GKRPTFFEV
Xtro
MAA............PQ........................LGKSVFYDL
Tnig
MDI............PS........................KN...LYEC
Frub
MDF............PS........................KN...LYEV
Spur
METTPTSTQARYVSQGCQKHTKLRHRPLQFVYDFKSGQHSVHSNTSLTSL
 
FKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKT
FKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKT
FKTRCNKADLGPISLNWFEELSSEAAPYNSEPAEDSEHKNNNYEPNLFKT
FKARCSTADLGPISLNWFEELFSEAPPYNTEHPEESEYKPQGHEPQLFKT
FKTRCNQADLGPISLNWFEELSLEAPPYNSEPTEESGYKIS.YEPNLFKT
FKARCNKADLGPISLNWFEELSSEAPLCNSEPLEESEYKISSNETNPFKT
FKTRCSESDLGPISLNWFEELTSEAPPYNYEISEDPGSKTEITEVNYFKT
FKAHCSDSDLGPISLDWFEELSSEAPPYEPKLLGEPEGPIG.WFDQTFKT
FSTHCSHSDLGPISLNWFEELTAEALPYKSRTCEDHECSLDDLHENNIKT
FKDEIWK.GLGQLDPDWFEVLTSQTLTKEENIFNQDD.....LCPN..QE
FKDEIWK.DLGPLDPDWFQVLTLQALTNEGNISFQDD.....LCPN..QE
FEESSLCSSLGEVDTSWFDSERWTS...NDE........TKWKKEDILKT
 
PQRKP.SYNQLASTPIIFKEQGLTLPLY.QSPVKELDKF......K....
PQRKP.SYNQLASTPIIFKEQGLTLPLY.QSPVKELDKF......K....
PQRKP.SYNQLASTPIIFKDQGLTLPLY.QSPVKELDTF......R....
PQRNP.SYHQFASTPIMFKEQSQTLPLD.QSPFKEL..............
PQRKP..YNQLASTPIVFRE.....PIYQQSPLKELDKY......R....
PQRKP..YHQLASTPVIFKEQSLTLPLY.QSPLKELHKF......R....
PQRKPFTYNQLASTPLIFKEQNVNCSLN.SSPLSGPDHC......K....
PKAKSSTDSQLASTPLIFKEQNT.MPPF.SSPGKELDQK......K....
PKLKSSIYSQLDSTPVIFKERLLS.PLF.ASSSTELDKR......QNA..
GNYKPTSDSLLFSTPKVFRKCRVV.SP.....ENE.EQS...........
GHFKPAIDSQLFSTPKLFRHCQVL.SP.....ETEREQL...........
PQASQ.RENKACSTPGLFTPDGLS.PVA.RRGHKDYPDCHPLPDDESASS
 
..........................LDLGRNVPNSR..HKSLRTVKTKM
..........................LDLGRNVPNSR..HKSLCTVKTKM
..........................LDLGRNVPSSK..HKSLRTVKAEM
.............................GNVVANSK..RKHHSKKKARK
..........................LDSGKDITDSK..HKSCCTMKSKM
..........................LDSGKDIANSK..HKSCCRVKAKI
..........................LDLGKDTAMDKELRKSHCVLKTKL
..........................METSRENLLS....P..SMAGRKT
..........................TDNGNNVRLE....KSNCTQMQ..
..........................FADGHEKEK...............
..........................LADGHENDR...............
FLRPKRFRKVPSSIHTTPNSQIITSHQPTSGPTAETI..EEEEEEDKGEV
 
DQADDV.SCPLLNS...CLSESPVVLQCTHVTPQRDK...........SV
DQADDV.SCPLLNS...CLSESPVVLQCTHVTPQRDK...........SV
HQADDV.TCPLLNS...CLSESPVVLQCTHVTPQRDK...........SV
DPVVDV.ASLPLKA...CPSESPCTPRCTQVAPQRRK...........PV
DRANDV.TSPPLNS...YLSESP.VLRCTHVTPQREK...........SV
NQANDV.ISPPPNS...SLSESPVVLRCTHVTPQREK...........SV
GQANDV.TSPPLST...CLSESPAVLRGAYRTPQREK...........PV
DQENQI.LASPHGICHNYTAASPAIVRNPCRTPQRSN..........IPG
HQASEV.FSPS.SR...CLNESPAVIKEIFKTPLRNKYLHKTPQCDWKPD
..........L.PW...VPTQSPCLFK....ISKDGNP..........CP
..........L.PW...MPTQSPCLL......PKDGIH..........CP
AQSADIQFSPYPTWNPTFHKDTPVFMKQLFKTPSTL............FG
 
VCGSLFHTPKFVKGRQTPKHISESLGAEVD.PDMSWSSSLATPPTLSS..
VCGSLFHTPKFVKGRQTPKHISESLGAEVD.PDMSWSSSLATPPTLSS..
VCGSLFHTPKFVKGRQTPKHISESLGAEVD.PDMSWSSSLATPPTLSS..
VSGSLFYTPKLE...ETPKHISESLGVEVD.PDMSWTSSLATPPTLSS..
VCGSLFHTPKLMKG.QTPKRISESLGAEVD.SDMSWSSSLATPPTLSS..
VCGSLFHTPKLIKG.QTPKRISESLGAEVD.PDMSWSSSLATPPTLSS..
AYGNLLYTPKLMKV.NTPKHISESLGAEVD.PDMSWSSSLATPPTLSS..
PYGSLFCTPKFLEI.PTPKRISESLGAEVD.PEMSWTSSLATPPTLGV..
ICSSLFCTPKLMK..NQTGCIKESLGAEVD.PEMSWSSSLATPPS..P..
TYGGILDASQNFPS.SYVKRISESLGPEIH.PDISWTSSLNTPPP..S..
VYGGILGASQHFPS.SHVKRISESLGAEIH.PDISWTSSLNTPPP..S..
AGDKRACSTPLQRL.STPQRLSRSLGAEPEESDLSWTSSLATPPMSSKGC
 
......TVLIVRNE.....EASETV.FPHDT.TANVKSYFSNHDE.....
......TVLIVRNE.....EASETV.FPHDT.TANVKSYFSNHDE.....
......TVLIVRNE.....EASETL.FPHDT.TANVKSYFSNHDK.....
......TVLIARDE.....EAHRNA.FPADS.PASLKSYFSNHNE.....
......TVLIVRDE.....EVSAAV.FPNDT.TAIFKSCFSNHDE.....
......TVLIVQDE.....EASAAV.FPRDT.TAILKTYFSNHDE.....
......TVLIVRDG.....QTPGAR.TPDDT.TIMLQKYLSQHGE.....
......TVIIAREN.....DSISGAKQQDERAEIVLHNFLSEDDG.....
......TVIIAHAN.....DQPSGN....K.HAAIVQSLFPNCEN.....
......TLILSPPD.....ESPCPASLSAEGNVVFVRKLFP.........
......TLILPKPD.....ESPCPVSLSEERNVVLVRKLFP.........
KTVTSSTKKVIEDDSWQTHDVAKVL.FQDGGSVAEMDSC.DEGDEGLTQP
 
.......................SLKKNDRFIASVT..............
.......................SLKKNDRFIASVT..............
.......................SLKKNDRCIPSVT..............
.......................SLKKNDRFIPSVS..............
.......................SLKKNDRFIPCGP..............
.......................SLK.NNKFIPSGP..............
.......................RPKRLDRSTSSVP..............
.......................YTAKNDTSLLSIP..............
.......................MEA.NN...LPPP..............
.......................SLSNPSRAVVASP..............
.......................SLSNPSRAVVASP..............
LQVIKLPSITDESQEEEFTIETEDGGESDKSIADGSKAIAALGNEQCSRF
 
.......DSENTNQR.EAASHGFGK.TSGNSF.KVNS......CKDHIG.
.......DSENTNQR.EATSHGFGK.TSGNSF.KVNS......CKDHTG.
.......DSENTNQR.EATSHRFGR.TLGNSF.KVNS......CKDHIG.
.......DSENKSQQ.EAFSQGLEK.MLGDSSSKINR......FRDCLR.
.......GKENKNQR.EAKSQSL.....GNSFGKVNS......TKDHFV.
.......DSDNKNQT.KAESHGLEK.MLEDSFGKVNS......CKDRFE.
.......NIENIHAEGYGTSQELEK.MIDDSFDDGNN......FKDHGGK
.......ETVKLNAR.DDI.KDLESEVLDGLFGETNS......FEDSFNL
.......ETGTQNED.RQICAGLEK.PGSCSASKAVPEASAISSRAAWK.
.......KNNNL....TTVHEGVYCGDNDNSEAPNPS..QSGKSNCVWK.
.......KNNNL....TTVHKGDYRGGNDNPEGRNNS..Q...GTCDWK.
DVVGGATSPDNLKNDQDGTRTVMNN.SLVP...PTTS.VQ..SSMT.Y..
 
.......KSMPNVLE.DE.VYETVVD.TSE...EDSFSLCFSKCRTKNLQ
.......KSMPNVLE.DE.VYETVVD.TSE...EDSFSLCFSKCRTKNLQ
.......KSMPNVLE.DE.VYETVVD.TSE...EDSFSLCFSKCRTGNLQ
.......KPIPNVLE.DG...ETAVD.TSG...EDSFSLCFPKRRTRNLQ
.......KSTPNVLE.DE.VHEKVLD.VSE.E.EDSFSLCVPKYKTRNLQ
.......KSMPNVLE.HE.VHETVAG.ISE...EDSLPVCVSKYKTKKLQ
......MINMPNIME.EE.ICDPIIN.TPV...EDDASFNFTGYIVGNLR
PAESSGILLSPRALDAIE.KCEIKID.EAQ.EKSDVLSEQHRRRKSTISQ
.......KTVANTVK.DEE.VSRTVENALEGM.EDVLSIFFASEKTPGLR
.......QKLPVATE.DRELRSTVES.VLAGA.EDVLSVFFTN.PSPALR
.......QKLPDAIE.DQELRSTVAS.VLEGA.EDVLTVFFTN.PSSTLK
.......HGKPHLAK.DEE.HESVGEY...AV.PDQY....VDEKASVRE
 
KVRTSK......TR.KKIF.HEANADECEKSKNQVKE.KY..SFVSEVEP
KVRTSK......TR.KKIF.HEANADECEKSKNQVKE.KY..SFVSEVEP
KVRTSK......TR.KKIF.HEANADECEKSKNQVKE.KY..SFVSEMES
KTRMGK......MK.KKIF.SETRTDGLSEEARGQADDKN..SFALEIEP
KIKTSK......TR.KNIF.NETKTSECEEAKKQMKENKH..SLVSEMEP
KRKTGK......SR.KNIF.HETKTDECEEAKKEMTESKH..SFVSETEP
KVKCDK......TR.KK.Y.SKTKTNEYEDTKNLSKKENY..SSASETEL
EVKAAN......WTEKSCC.VEVKDSIIQNTNEDIMDSKDNCLLGREKE.
KLKNST......QAR.RKV.ESIKSQKCQVSLFKAEEGES..ILVPLDEH
KVKTDR......VR.WKQM.AHVTKDDNTSADLKTSDPTV..SSEQKSSH
KVKTDR......VK.GKEM.AQKTKDNSIPTDMGTSEHPV..SSDETTAH
KVEDMDNAAELKSRT.IANGECTDTNVTSKLAHGSHSMKN..HLHVPIQP
 
NDT.DPLDSNVAH...QKPFESG.SDKISKEVV..........PSLACEW
NDT.DPLDSNVAN...QKPFESG.SDKISKEVV..........PSLACEW
SDT.DPLDSNVAN...QKPFESG.SDKISKEVV..........PSLACEW
RDS.EPLDPSVTN...QKPLYSQ.SGDISSEAG..........QCSDSIW
NDS.HPLDWNVTH...EKPFGNG.TDKISKEIV..........LSSASGC
NDS.DPLDSNVIK...QKPVGNG.TDIISREVL..........PSSVSEW
EYC.YPLISKAENNEIQKSIKNV.NEEMLEDDV..........PSSATQW
LEY.LRIAGNLQD...NRTQKSSVNEKLVKD.V..........LSSSSQW
HKCDHEMLMKPEQ...DYKMNA.VNQKIAKE.............TTPYEW
QET.EGHSP.......PPPLNAG.NV...................GITQW
RET.EGHSP.......TAPLKTG.DV...................RVTQW
TMS.SQQSSIIGS...SQTLFN.SQESIKNEKSAIEETLAFLLATPPSRR
 
SQ.LTLSGLNGA......QMEKI..PLLHISSCDQ.NISEKDLLDTE...
SQ.LTLSGLNGA......QMEKI..PLLHISSCDQ.NISEKDLLDTE...
SQ.LTLSGLNGT......QMEKI..PLLHISSCDQ.NNSEKDLLNTE...
SQ.PDPSGLNGT......QTRKI..PLLHISFHKQ.SILE.DFIDMK...
SD.LTLSSLNGA......QMEKT..PLLH.TSYDQ.NNSEKDLIITD...
SQ.LTLSGLNGT......QVQKT..SLLHISSCDQ.TNSEEDLIGTE...
SQ.LNLSGLDVT......QIEKT..PLPHISFCVQ.NSEE.RPANES...
SQ.LNLSGLDVT......HLEMSICSSPQSDSCREKGLEEK.SVLMT...
SQ.LNICELDIT......QSQDS..TLHAAN......LCCEDITVNK...
SP.LSLSEIPLF......TGD..........AYDH.TIPTKE........
SP.LSLSEILVS......TGH..........TYEQ.NTSSKE........
EKLLNRLGTSSSGIGETTSFEKA...ACDAA......GSTLDGRSDSPVT
 
.......NKRKKDFLTS......ENSLPRISSLPK.SEKPLN...EETVV
.......NKRKKDFLTS......ENSLPRISSLPK.SEKPLN...EETVV
.......NERKKDFLTS......ENSLPHISSLPK.SEKPLN...EETVV
........KEGTGSIT..........FPHISSLPE.PEKMFS...EETLV
........KECTNFITL......ENSWPQISNVPKYSEKTLN...EEIVV
........KECTNFITL......ENSLPHISSISK.TVKILN...KETVV
........NECSSLSTL......KT....................VEIAA
........KDDAVETSL......LNT.SGLRNAQELSSASLSENGSDTKI
........SDTCN...................................IT
..................................................
..................................................
SNSVPKKSTSDDTLMSPPVGLLWKRSIPGHLSGGPERNSLE....SECSV
 
NKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKK......SIFRIR
NKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKK......SIFRIR
NKRDEEQHLESHRDYILAVKQAVSETSPMASSFQGIKK......SIFRIR
DKEHEGQHLESLEDSI.SGKQMVSGTSQTACLSPSIRK......SIVKMR
NKINEGQCLESHEDSVVSVKQAIYETTLIASPLQGIRK......SIFRIR
NKTDEGQCLESHEDPTTVGKQILTDS....SPLQDTKK......SIFRIR
YKEDEEKITTPNKGSVMLLKQISPEISPPNAISQDRKN......SKFKMR
SKNNPMSEITPVKPVCASPKLVKGYAHEEVSGMSFLNC......SSFLI.
EAEKQEEVNEPSTDNVLSNKVGKESTLNVNCINADLNN......M...AS
DK................................................
EV................................................
DAKTNGQVGETPNRPA.......PDVDMLSPISPNFAEALCRVTDIASRE
 
ESP......................KETFNASFSGHM...........T.
ESP......................KETFNASFSGHM...........T.
ESP......................KETFSASFSGHV...........T.
EPL......................EETLDTVFSDSM...........T.
ESP......................EGMSNAMFSNNM...........T.
ESP......................EKIFREDFSNNV...........T.
QTS......................EETVSMDFLECS.........SLCT
EST......................NVMEYSVVYNST...........F.
SSN......................NSVHSLNLSQCEK............
..................................................
..................................................
QPSSNKSTLTVQKCLEVERNLVGDFDSPDPDTAVSHIKVVDQSTSEDHT.
 
.DPNF.........KKETEASESGLEIH...TVCSQKEDSLCPNLIDNGS
.DPNF.........KKETEASESGLEIH...TVCSQKEDSLCPNLIDNGS
.DPNF.........KKETEASESGLEIH...TVCSRKDDSLCPNSIDNGS
.SSAF.........TEELDASAGGLEIH...TACSQREDSLCPSSVDTGS
.NPNF.........KE.PEASESGLEKH...TICSQKEDSLCTSSIDDGS
.DSNL.........KEEPEDSKSESEIQ...TIYSQKEDSVCSSSGDNES
VNASITT..EAKVFENKLENPKSSL.DD...IICPEKHGLLSPNTDGKGS
.STHL.........KAT.SQSVVTDVLSHP.LICSAASPDNCSDLHLRN.
..............MDSSEISNSEVG.......CITKLTTHPAKMATTGE
..................NDSRVAKELQQD.FECGQRERP..........
..................KNLRAPEELQRD.VDIGKQERP..........
.DIVVKQSLHPTE.ITGENAIAGHLSAPITSSLPSSAKNKLPKHLSKQEP
 
WPAT...TTQNSVALKNAGLISTLKKKTNKFIYAIHDETFYKGKKIPKDQ
WPAT...TTQTSVALKNAGLISTLKKKTNKFIYAIHDETSYKGKKIPKDQ
WPAA...TTQTSVASKNAGLISTLKKKTNKFIYAIRDETSYQGKKIPKDQ
WPTT...LTDTSATVKNAGLITTLKNKRRKFIYSVSDDASHQGKKLQTQR
WPAT...IKHTSVALKNLGLISSLKKKTKKFIYVINDETSNQGLKTQKDQ
WPAT...TKYTSEALKNTGLISTLKKKTKKFIYVINDKTAYQGLKIQKDQ
CATV...SKRNSAPLNSTGIISHFKKRTKKFIYVVNNDSSYQGEKIQKTQ
..TE...NTLRKSNFKSLNMLSRLRKKSKRFIYTINNTLVYQEENVQKEV
LSSVDDCAKKPQERVTISTSFSTLKKQS.KFMYSVNTVLTGHIASNTSIA
..............QVST.GHTGLAKKKRKFVYTVETPKRQTLVDARPPK
..............RVNT.RHIGLTKKKRTFVYTVETPKRQNLAGIQSQK
SPVV...PPSRSLAVSNL...NTQTTAKGRFKYTAAVPRKDGASTSKTPS
 
KSELINCSA..QFEAN.....AFE....APLTFANADSGLL.HSSVKRSC
KSELINCSA..QFEAN.....AFE....APLTFANADSGLL.HSSVKRSC
KSELMNCSA..QFEAN.....AFE....APLTFANADSGLF.HSSVKRSC
QSELTNLSA..PFEAS.....AFE....VPFPFTNVDSGIP.DSSIKRSN
ESRLINLST..QFEAN.....AFE....GPLTFTNADSGLLHSSSIKKNC
ESELTNSSA..QFEAK.....PLE....APHTFTNVDSGSL.PSSIQKKC
EFGSVNCSASSHLELN.....SFE....EHHEFTNAISDFL.DSSIRRKC
TSESPDNPVLTHLESD.....LHE....FKDCQVATDDCLL.SAERQSNI
TRRSLN..S..HLSSDEPKPHIKENQNEPESNAKYYSNGLQKPVFLEK..
VESFP.............................................
EESFP.............................................
WLSRA.....IYVEED.........EEEDKTA...........DAVQADT
 
SQNDSEEPTLSLTSSFGTILRKCSRNETC.SNNTVISQDLDYKEAKCNKE
SQNDSEEPTLSLTSSFGTILRKCSRNETC.SNNTVISQDLDYKEAKCNKE
SQNYSEEPTLSLTSSFGTILRKCSRNETCSSNNTIISQDLDYKEAKCNKE
LPNDPEEPSLSLTNSFVTAASKEI.....SYIHALISQDLNDKEAILSEE
LQNDSEKPALSLTSSFGTILRKVSSNGASSPNNKIISQDPDYKEAKINKK
SQNDSEEPTLSLTSSFGTVLRKCFNNESSSSTNKTISQDLYCKETNINKE
SQFDPKEETAPLTECDKTMMEEYFH.ESRFPHNEVTSQDLGFREVEMNKG
KENNLN..TLTI...KVDIMD....NSSDNSVNNRLKQELS..ESGKNAR
.ENDNKGISLC......................KTISDGQNTSEG.....
..................................TIQQDVHVKALAKAPE
..................................VIQQDVYVTTMAK..E
IKDESSK....................................KPWIMKR
 
KLQLFITPEADSLSCLQEGQCENDPKSKKVSDIKEEVLAAACHP.V.QHS
KLQLFITPEADSLSCLQEGQCENDPKSKKVSDIKEEVLAAACHP.V.QHS
KLQLFITPEAHSLSFPQEGQYENDPKSRKVSDIKEEVLAAAHHP.V.QHS
KPQPYTALEADFLSCLPERSCENDQKSPKVSDRKEKVLVSACRPSGRLAA
KLESFITTETDCLSSLQEKHWEDDAKKQRVSDIKEKVLPTVSHPPV.PHS
KWQSFITTETDYVSCLQDKHCEDNPKSQGVSDIKEKVLPVVCRPEL.PHS
ELESDIT.ETDNQSQSQERSYNDFSKRQRDSHVKECILTATCLSPR.KHT
EYQPATSFKCLKASHTESEDTTDCLNSGRISNIKHKVLTSAYLMARR.HS
.........ARAPDYFEERVPETKDRCKATLSIREKVVATANCFAR.KQL
QVSGCCGMKNDLKS...............QIDLSEEHLH...........
QVSGCSVKENDAKC...............QADLTEKSLH...........
PCRTATTF...........................KTFSTFCKTAPNPPS
 
KVEYSDT....DFQSQKSLLYDHENASTLILTP.TSKDVLSNL.......
KVEYSDT....DFQSQKSLLYDHENASTLILTP.TSKDVLSNL.......
KAEYSDT....DFQSQKSPLYDHENASTLILTP.TSKDVLSNL.......
AVQLSSI....SFDSQENPLGSHNVTSTLKLTP.SPKTPLSKP.......
EVEGSDI....HFQSPESFSFDCDNTS..LLTP.SSRDSPSSL.......
E.ECSDT....VFQFQESFLHDHDNTT..ILTP.SSKDLLSNP.......
EIELGNIAENSHFTTKNSTLHDSVDTSINSLTQ.LPQDPQELS.......
RLFPEDC....CLRKGKNDTYTVSNVNSRAAVPWSPKGQPPQSSPSCSDC
ET................................................
..................................................
..................................................
...........STQSQTGPRTSTTPTSSRSI.V.QSAPPHNKT.......
 
VMISRGKES.YKMSDKLKGNNYESDV........ELTKNIPMEKNQDVCA
VMISRGKES.YKMSDKLKGNNYESDV........ELTKNIPMEKNQDVCA
VKISRGKES.YKMSDELKGNNYESDF........ELTKNIPMEKNQDVCA
VVVSRGK..MCKMPEKLQCKSCKDNI........ELSKNIPLGVN.EMCV
VVMSRGKES.YKISEKLKCKNHETGF........ELTKNIPMEKNQDIHV
VVIPRGKQS.YKMSEKIKSKNCEAGF........ELTKYISMEDNQETCV
VVIYGKKEPLCKVKQKLRFRRNSDSTFITNKVRSELKESFGNKGNQETEV
LIDMHHGTA.FVTNSKF..NNTLSHI........KFGMNRVSSNSCNK.I
..................................................
..................................................
..................................................
LVRIREIPHSWPSPKRLRLDEEREECPIGNDLKSL...............
 
LNENYKNVELLPPEKYMRVASPSRKVQFNQNTNLRVIQKN.QEETTSISK
LNENYKNVELLPPEKYMRVASPSRKVQFNQNTNLRVIQNN.QEETTSISK
LSENSKHVELLPPEKYIRVASPSRKVQFNQNTNLRVIQKD.QEETTLIPK
LSENSETPELLPPLEYITEVSSSVKSQFNQNTKIAVVQKD.QKDSTFISE
LNADSKNAKLLSTEKHITVASSSVKVQFNQNANLTTIQKD.QKETTLISK
LNENSKKAEMLSPEKYITGALPSVKVQCHQNMNLTVIHKD.QEETTLISK
LNEILGDDRELSSEKCKEMTSVSLGAQVNKNAGLFVSLRD.QENTNLITE
SADKRRASDQLSVAECREIVA.PLGINCLENNSTSLKQRG.KED......
..................................................
.....................PLVKAKL.QDLDMSQLSKDFAQDFSQIPE
.....................PSVKAKL.QDLDISQLSKDFAQDFSQMPE
...SPAVDEHDGEITKSTPLESDVKSHHVQDVVSLHVEEG.VEDQKDLGD
 
IT.VNPD.SEELFSDNENNFVFQVANERNNLALGNTK.ELHETDLTCVNE
IT.VNPD.SEELFSDNENNFVFQVANERNNLALGNTK.ELHETDLTCVNE
IT.VNPD.SEELFSDNENNFVFQVANERNNFALGNTK.ELHETDLTCVNE
VT.VHMN.SEELFPEKENNFAFQVTNESNKPNIGSTV.EFQEEDLSHAKG
IT.VNPN.SEELFPDDENNFVLKITNESNTPVLGNTK.ELHDSNLCCVRD
RT.VNPN.SEELSPDSENNYIFQTTSERNIPILGNIK.EVHEADLSCLRE
KTAIELY.SEENLHFNEENFIFQTIDKKNIRVTDSSE.EFFATSFCYLEE
...VDEN.........QETLSIKSSENRQAAAWNNESIEVAEEFLDCID.
......D.YPEDASAQHEALQFHAKQYVSCSMLNSN..............
LS.FLKDTSQNIFSPSACLSALKQASKERKADNSHEC.DVSISSVTAP..
PN.FAKDTS.DVFSPSACLSALKRANKKGQADISTER.DVGNRSVIAS..
FH.DKVN.SEDLVPSSEGDL..............................
 
PIFKNSTMVLYGDTGDKQATQVSIKKD.....LVYVLA....EENKNSVK
PIFKNSTMVLYGDTGDKQATQVSIKKD.....LVYVLA....EENKNSVK
PIFKNSTMVLYADIGDKQATQVSIKKDLDSSNTVYDLA....EENKNSVK
HSLKNSPMTVDRDLDDEQAGQVLITEDSDSLAVVHDCT....KKSRNTIE
SVPKNSTMVVCTDLDDKQTAKVSIMKDCYSS.SIDDLT....ERNRSTIK
PVLKNSVRVTSTDMDGGQAAKVSITKDSVSSNTVHGLI....EKNRNSVK
SIPKNST.....EIDYKQTVQELFMEDSFSSEMVPVFTRDSQDKNQNSKL
NSLNEVV.....SEEDRQVAPVYF..........................
..................................................
..................................................
..................................................
..................................................
 
QHIKMTLGQDLKSDISLNIDKIPEKNND.YMNKWAGLLGPISNHSFGGSF
QHIKMTLGQDLKSDISLNIDKIPDKNND.YMDKWAGLLGPISNHSFGGSF
QHLKMTLGQDLQPDI.LNIDK.............................
QHQKGTADKDFKSNSSLYL..KSDGNND.YLDKWSEFLDPLMNHKLGGSF
QQLKMTLDQDSKSDITSDIVRKSNGNSD.YMDNWARLSDPISNHSFENGF
QQSKMTLGQDSKPDVSLDTDTKSNRNNF.CKDKWAGLSDLTSSHSFGNGF
ACECISQSKSSYSKSTIDTNMKPKRNEENYLGKWAQNFDPDSNKSFGCGF
...................NTKPIESLE.HKGKSSGDLNACSSSLSFGGF
........................VSN.DMQIKP.......QVLTDFKGF
.........................NQ.NVLLN........GSTIIAPGL
.........................NQ.KSLID........ESATVASGF
.........................................HQMAPNVGF
 
RTASNKEIKLSEHNIKKSKMFFKDIEEQYPT.SLACVEIVNT........
RTASNKEIKLSEHNIKKSKMFFKDIEEQYPT.SLACVEIVNT........
........................................NT........
RTASNKEIKLSEDNVKKSKMFFKDIEEQYPT.SLDCIDTVST........
KTASNKEIKLSENNIRKSKMLFKDIEEHYPT.NLACLEIVNT........
RTASNKEIKLSEHNIKKSKMLFKDIEEHYPA.SLPWVEIVKS........
KTASNKEIILSEHNIKKGKLFFKDIEQYYNS.S..SVEVVNSSI.....S
QTASNKQIKFSESSIAKGKMLFKDIENEFEFFEASSMERVRN........
KTASNKDIIISESTLAKGKLIFEDIEDTRYSETGRTIDCKAKGGALSTSN
KTGPNKGRLVLSANLERAKHVFQETISDPSKK...SIH............
KTASNKGIHVLSDNLERAKHVFEESVSEPSGK...GIC............
SSASGKAIFVSPEALKKAERLLEDVDREKPPE...E..............
 
LALDNQ........KKLSKP.....QSI................NT....
LALDNQ........KKLSKP.....QSI................NT....
LALDNQ........KKLSKP.....QSI................NT....
LQLANK........KRLSEPHTFDLKSG................TT....
SSLESQ........KKPSKSHALDPQSI................NI....
..LENQ........RKGGQPRDRDSQSV................DT....
VAAENIKTDSDSKKQEKNSFPAWKSEPS................HI....
FSNRVQ........KENIFSSDLESKTG................ST....
LVMHNT........MCKNEPSTSENTNDKAPKRAKVQTPMAENSHLKEPS
..................................................
..................................................
..................................................
 
..............VSAH.LQSSVVVSDCKNSHI.TPQMLFSKQDFNSNH
..............VSAH.LQSSVVVSDCKNSHI.TPQMLFSKQDFNSNH
..............VSAH.LQSSVVVSDCKNSHI.TPQMSFSKQDFNSNH
..............VSTQ.CHSQSSVSH.EDTHT.APQMLSSKQDFHSSH
..............ISGF.VQNSTYVSDSESGHT.APPTLSLKQDFDSNR
..............VCGY.VQSGAVVSDGENSHT.TPPVLSLKQDFNSNH
..............ISKD.VQSNIFVLNEKEIDP.ALEDLCSEKDLDLNH
..............SSGLQTRCMQYIPRKVDLCKNSPRNQLSVQ..EPNQ
SDKNAMDAANHQMTLKAS.AYSPKAASSALPRYK.KKPISTTKTSFQLNE
..............DSKD.ELGLTHNSAKTPTCNSHQTLSLIGKNAENSP
..............LSKD.ELGLIHKSAKKTTSNSNRTLSL......SGP
..............FQLN.Q.GNAVVPEI..................QST
 
NLTPSQKAEITELSTILEESGSQFE..FTQFRKPSYILQKSTFEVPENQM
NLTPSQKAEITELSTILEESGSQFE..FTQFRKPSYILQKSTFEVPENQM
NLTPSQKAEITELSTILEESGSQFE..FTQFRKPSYILQKNTFEVPENQV
NLTPSQKAEITELSTILEESGSQFE..FTQFKNPSHIAQNNTSAVLGNQM
NLTPSQKAEITELSTILEESGSQFE..FTQFRKPSHIIQKNPFEMPENQL
NLTPSQKAEITELSTILEESGSQFE..FTQFRKPSHILQSNPFEMPETQM
SLTASQKAEITELSTILEETGSQFE..FTQFRKQSSTVQTLDISTNKADE
SLTASQEAEIAELSNILEETGSQFEFEFTQFRKQSNMIQSHIQQFGATNV
HLTESQQAEISELSSILENADSQFD..FTQFRKVPSVTEKQNSTEGGSES
HLTASQKADMTELCTLLEEADSQFE..FTQFQTAETKLPGQENTTSPKKP
HLTASQKADMTELCTLLEEADSQFE..FTQFRTAETKEPWQENTTSSKKE
TLQVEQKIETSESSIILEQTQDKQE..NTDSMNG.QLVDNGELEISEDEC
 
TILKTTSEECRDADL..................HVIMNAPSIGQVDSSK.
TILKTISEECRDADL..................HVIMNAPSIGQVDSSK.
TILNTTSEENIEAGL...................VIMNAPSIGQVDSSK.
AVVRTASEEWKDVDL..................HLPLNPSSVGQIDHNK.
TILNSTSKEWKDDDL..................HLTTNAPSISQVDS.K.
TVLNTTSEEQKDVDL..................HLTASAPSLSHIDSSK.
LGNLNTFELQMGVEL...........GDHFGAEYETDNNRSPVQVDLNV.
EN...ASEAGGDTNFYSTLKSENHVINDEYC..SKLKNENECKMVEYEK.
QNL.NNSDVWKDVDF...........NDSFAAGRDHSEGMEAIPSSPGIK
..................................................
..................................................
LSA...............................................
 
..QFEGTVEIKRKFAGLLKNDCN.....KSASGY.LTDENEVGFRGFYSA
..QFEGTVEIKRKFAGLLKNDCN.....KSASGY.LTDENEVGFRGFYSA
..QFEGTVGIKQKFAGLLKNDCN.....KSASGY.LTDENEVEFRGFYSA
..KFECLVGVKQSSSHLLEDTCN.....QNTSCF.LPIK.EMEFGGFCSA
..KSEGIIGGKQKFACLSRTSCN.....RSASGY.STDKNEVEFRGFYSA
..KCEGLAGREQKMICLSTTNCN.....KSVSGS.LTDKGEEEFRGFYSA
..NSEVVINVKQRTVYLPKSNSE.....QGASTD.IFT..ESEFKGFCSA
..EDTVVFHKNKRKVTFTNLDRNESRISSHESCPVPLRDSFSNFVGFTSA
ELPSAGECCSKETHDSMPDFVTL.....APKQGF.LVKQNERLFAGFNLA
....EGNISKEQMHSKMP..................VSDPPARSCGFRTA
....EGKIRKEQIHFKMP..................FAEPPARSSGFHTA
...STITFKTAQGQKDEPGARMDDNN...........I.EEHDPVGFKTA
 
HGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSSSKCHDSVVSM
HGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSSSKCHDSVVSM
HGVKLNVSTEALQKAVKLFSDIENISEETSAEVDPISLSSSKFHDSVVSM
LGTKLSVSNEALRKAMKLFSDIENISEEPSTKVGPRGFSSCAHHDSVASV
RGTKLNVGSEALQKAKKLFSDLENINEETSVEVDR.SFSSSKYNDS.VSM
RGTKLNVSTEALQKAMKLFSDIEKVSEKTPAEVDPGSFSSNQCNNSDVSM
LGRKMNVSNEALQKAMKLFSDIEEIGEGTPLQNLRNGPLDRSQKSNIVPA
GGKKINISKAALTRSAELFKDLDDDNFLFKSSG.....TNTRCCNSDGRV
SGKQVNIDNDVLKKAAELFNDIDNDKELLSHAKEESRKSNIKHSSK....
SGKAATCSSEALQKAKALFSDISSNEDTGQADHADPE...QEK.......
SGKATACSSEALQKAKALFSDISSNVETLQTNHDDRK...RDH.......
GGKKIQVSESALQKATLLLSDCNSDVETMKESS.......LEISDELLNQ
 
FKIENH.ND.KTVSEKNNKCQLILQNNIEMTTGT.......FVEEITENY
FKIENH.ND.KTVSEKNNKCQLILQNNIEMTTGT.......SVEEITENY
FKIENH.ND.KTVSGKN.KCQLILQNNIEMTTGT.......FVEEITENY
FKIKKQNTD.KSFDEKSSKCQVTVQNNKEMTTCI.......LVDENPENY
IQIEDC.ND.KNLNEKNNKCRLILQNNIEMTTDI.......FVEEYTESY
FKVENYSND.KNLSEENNKCQLILQSNFEMTTSI.......FVKENTEDF
FKIANYANNSKDFKGKDAK....PQSNAENNTGI.......FVEENMLNC
SS..NW.NF.LRCQTKEDEGGILCVPNIKSVGPISHHSEKKYAENISSPC
..LINNENCG...KTEHTSEHLVCQSNVSLPFIK.......TLGKNATIL
..................................................
..................................................
LIPTSSAHD..................ICISDAT.......TLAENVELC
 
KRNTENEDNKYTAASRNSHNL.EFDGSDSSKNDTVCIHKDETDLL.FT.D
KRNTENEDNKYTASSRNSHNL.EFDGSDSSKNDTVCIHKDETDLL.FT.D
KINTENEDNKYTAASRNSRNL.EFVGSDSSKNDTVCIHKDEKDLP.FT.D
VKNIK.QDNNYTGSQRNAYKLENSDVSKSSTSGTVYINKGDSDLP.FAAE
RRNTENEGNQCTDAGRNTCNS.ESDGSDSSKNDTVYIHEEENGLP.CI.D
KRNTENKDNKCVGFVCNL..G.ESDGCASSKNDTVYVHKDESGLP.YT.D
SRDPENKQSSSPLFISSHKD..SSKLKGSVEPDSDNSQREKNDLS.SI.D
KENTENWTEIL............SDNVDFSCTNGGYSASGMRNSPSSF.K
VSGNE.............................................
..................................................
..................................................
KSEDQNAKASECIPPGDVLQ...REGMIT..HINSGCPVIRNDST.SV.D
 
QHNICLKLSGQFMKEGNTQIKED....LSDLTFLE.VAKAQEACHGNTSN
QHNICLKLSGQFMKEGNTQIKED....LSDLTFLE.VVKAQEACHGNTSN
QHNICLKLSGQFMKEGNTQIKEG....LSDLTFLE.VVKAQETCHGNTSN
KGNKYPESCTQYVREENAQIKES....VSDLTCLE.VMKAEETCHMKSSD
QHNIDLKLFSQFMKEGNTQIKEG....LSDLTCLE.VMKAEETSHVTMSN
QYNIHLKLSHHFMKEENIPIKES....LSDLTCLE.VMKAEET..FNKSN
QQ.NYPKMSIQLIRQENYPVKGG....LLDLNCLGKAVKDEKIFASNVSG
KPHQNCKNSDQFLNQGNSEVEGCLQEDTSYLICLGDNITSAEEHDLNVSD
.............KSQNQEL.........QLDCL....KCESTDVKHTP.
...............................................EN.
...............................................ED.
EHP.PSTLSS..IRECSPRVSPMLHP....NTSDS.DTSQNATCKMDNN.
 
.KEQLTATKTEQNI...KDFE..TSDTFFQTASGKNISVAKESFNKIVNF
.KEQLTATKTEQNI...KDFE..TSDTFFQTASGKNISVAKESFNKIVNF
.KEQLTATKTEQNI...KDFE..TFDISFQTASGKNISVTKESFNKIVNF
.KEQLPSDKMEQNM...KEFN.....ISFQTASGKNIRVSKESLNKSVNI
.KQQLTANT.GQNI...KDFD..TFYLSFQTASRKNIRVSKESLNKARSL
.KKEPIANKMRQNI...KDFG..VFDLSFWTANGKNIRVSKESLNKVVNF
.IEELVSNQEEQKM...RENENSSHLQSFQTASGRNIMVSKDSFSKVAHL
EMENLSPNQKEDRK...QEDE..HLLLNRQAADTDAVSISDSSFRSSLRD
QKETINDNSK.CNE...SSLS.ELSMKGFQTASGRNIMLSESSIQKARNI
.IDQLVPSQ..KPM...PP....LEKHGFQTASGKRVSISHAALAKAKSL
.TNRLAATQ..KLV...PS....LEKCGFQTASGKGVSISHEALRKAKTL
HK.TVQSEQVPQKCSSVTSTGLFPKTVGFQTASGNSVTVSEDSLSRARQL
 
FDQK..PEELHNFS..LNSELHSDIRKNKMDILSYE..ETDIVKHKILKE
FDQK..PEELHNFS..LNSELHSDIRKNKMDILSYE..ETDIVKHKILKE
FDPK..PEELHNFS..LNSKLHSDIRKNKMDILSHE..ETDTVKNKILKE
LDQE..TEDLTVTSDSLNSKILCGINKDKMHISCHK..KSIN.IKKVFEE
LNQKWTEEELNNFSDSLNSELLPGIDIKKTDISNHEVIENTERKDKITKE
FDEKCTEKELNNFSDSSNSELLSGININKIDISSHE..ETSMFKNKMLQE
FAEECSVKELNDFSFPFTLKMLNTALNKSVESSGKK....SENLAENEIE
LNVRCGERD.TDVSEKSSKQKTNS.......VSVEG..EDSTYKNLFVSE
FAEEH.E...DSFTLRCNIQNTIQIPQP..............VNEPTQFP
FQDCG.EDEGNISKEQMHSKMPV..QATENQE.DHSFKSCNTVDRQDDFS
LQDCG.EDEGKIRKEQIHFKMPF..SATENQEPDDSFKGCDIVDDRDDFS
FAEC...DAVSGTSSNTESGLK..IRECSPRVSPML.HPNTSDSDTSQNA
 
SVPVGT..GNQL.VTFQGQPE...R.DEKIKEPTLLGFHTASGKKVKIAK
SVPVGT..GNQL.VTFQGQPE...R.DEKIKEPTLLGFHTASGKKVKIAK
SVPVGT..GNQL.VTFQERPQ...G.DEKIKEPTLLGFHTASGKKVKITK
HFPIGT..VSQL.PALQQYPE...YEIESIKEPTLLSFHTASGKKVKIMQ
SDLIGT..ENIL.LILQQRPE...SKIKKIKESAVLGFHTASGKKIEITK
SSPAGI..ENQI.LTLQQREK...CEFKKIKEPTTLGFHTASGKKAKIAK
EMAVAT..KKEL.MPIQKGPK...IENKKWKEYNMVGFHTASGKEVTISK
SEIKIGSNQRHQ.VPSEQEMD...VDKNKVKGTYLTGFCTASGKKITIAD
YVNLGP..KPTT.TSGWQEKN...ILSRSTEKGFMPGFCTAGGKKVSVSD
VKHREA..LSALSGCDKEINH...SNVFTDALPSGCGFHTASGRKVSVSD
AKQRET..LAVV.SRFHEMNR...TNVCTNVPPAGHGFHMASGRKVSVSD
TCKMD.NNHKTV.QSEQ.VPQKCSSVTSTGLFPKTVGFQTASGNSVTVSE
 
ESLDKVKNLFDEKEQGTSEITSFSHQWAK.TLKYREACKD.LELACETIE
ESLDKVKNLFDEKEQGTSEITSFSHQWAK.TLKYREACKD.LELACETIE
ESLDKVKNLFDEKEQGTSEITSFSHQWAK.TLKYREACKD.LELACETVE
ESLDKVKNLFDET.QYVRKTTNFGHQESK.PLKDREDYKERLTLAYEKIE
ESLDKVKNLFEEKEQDNSEITNFSHRGAK.MSKDREECKDGRELACGTTE
ESLDKVKNLFDETKQDNSEVTDFIHQGAK.MLMDREVCKEGLDLACEIVK
ESLTKVKHFFVEENLEN.DVTNIKNLETE.FLNEREKINEKLVQAYEMVK
GFLAKAEEFFSENNVDLGKDDNDCFEDCL.RKCNKSYVKD.RDLC...MD
DSLAKAHKLFQEECT.FSKEGKLDEVKQNKFMNS.EPL...SLLTCESVL
IALMKAKSLLEESIT.LEGITEHQKPQI...QATENQEPDHSFKSCNTVD
EAMVKAKSLMDESVT.LEGRTEYQKPKI...SATENQEPDDSFKGCDIVD
DSLSRARQLFAECDAVSGTSSNTESGLK......................
 
ITAAPKCKEMQNSLNNDKNLVSIE.TVVPPKLLSDNLC...RQTENLKTS
ITTAPKCKEMQNSLNNDKNLVSIE.TVVPPKLLSDNLC...RQTENLKTS
ITTAPKCKEMQNSLNNDKNLVSIE.TVVPPKLLSDHLC...RQTENLKTS
VTA.SKCEEMQNF.......VSKQ.TEMLPQ.QNDHMY...RQTENLTSN
ITTTPEYEETHSSLEK.KKLVSNEIAALRPRLLSDNLY...KQTENLKIS
G.TAPKHEEMQNSLEE.KKLVSEE.TAMPPRFLSDHLQ...GQTENLHTS
LNNSQVCEEMQSFQDNDEKVLPVR.TTDLPK...........ITDSIL.S
S.TAHCDADVLN..FK.DKLIPEE........PGDRLKQTIEESPIIQAV
KQSDGFIEDIS........TSRN.ALEIRPELYPEGM.............
RQDDFSVKHREA........LSAL.SGCDKEINHSN..............
DRDDFSAKQRET........LAVV.SRF.HEMNRTN..............
..................................................
 
KSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTS
KSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTS
KSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKRS
GSS...PKVHGNIENKIEKNPRICCICQSSYFVTEDSALACYTGDSRKTC
DHASQKVDVHENTEKETAKKP.TMYTNQSTYSAIENSPLTFYTGHGRKIS
HSVSLKVKVHENMEEETAKSPITCYTNHSTCSAIENSALAFYTGHGRKIS
NEPSNNVLFEEKL.SEIKENCILSDAKQSTGLPVEMSGLGFYTGHGKSVP
NHDSIKVGAFINVDEDCERNLAAPCANKEAYVRPGKSEVQSLPVHGNN.S
........................CSNRASNGSGNNS..EFTAGEGISIN
.............................VFTDALPSGCGFHTASGRKVS
.............................VCTNVPPAGHGFHMASGRKVS
.............................APLQDQNIAVGFQTGHGKKVQ
 
VSQTSLLEAKKWLREGI.FDGQPERINT...........ADYVGNYLYEN
VSQTSLLEAKKWLREGI.FDGQPERINT...........ADYVGNYLYEN
VSQTSLLEAKQWLREGI.FDDQPERINT...........ADYVGNSLYEN
VGESSLSKGKKWLREQ...SDKLGTRNT.IEIQCVKEHTEDFAGNALYEH
VSEASLFEAKKWLREGE.WDDQSERINA.AKVNCLKEYPDDYVENPSCGN
VSQASLLEAKKWLREGE.LNDQPEKINS.SKIICLKEYTRDYVGNPSCGN
VSETSLLEARKWLKEID.LGGKTKASGMFVSSVDVKEDSDIHVKKSVPLY
LSRTLLLEDRKQFAERD.VEYSATKRDN.S......ESKPDSSLKCATSL
INQSSLLTTGNVLKNLP.SESSGH......DVYSVTEHLSTVVK....VK
VSDIALMKAKSLLEESITLEGI.............TEHQKPQI.......
VSDEAMVKAKSLMDESVTLEGR.............TEYQKPKI.......
ISEASLLKAKQFLAHEN.DPIRECSPR..........VSPMLHPNTSD..
 
NSNSTIAENDKNHLSEKQD.TYLSNSSMSNSYSYH..........SDEVY
NSNSTIAENDKNNLSAKQD.TYLSNSSMSNSYSYH..........SDEVY
NSKNTIAESDKNHPSEKQD.TTLNNSSMSNSCSYL..........SDEVY
SLVIIRTEIDTSHVSENQASTLFSDPNVCHSYLSH.....SSFCHHDDMH
SSNSAITENDKNHLSEKQGSTYLSNSTMSNSYSYH.....PGFCHSSEVY
SSNS.ITENDKS.LSEKQDSTSLNNS.MPNSYSYH.....SDFCHSSEGF
TSNNTSSIDDKN.ISDKQDAVFLSNSMSSIKHNLKHDTEGSDFCHSNDAD
HLTKVSSHLADNSVPGGIIQTVSAEDSCKSNQSF................
RYNDSGHFVNQN.LAECNDNHVLSTQKN......................
..................................................
..................................................
......SDTSQN.ATCKMDNNHKTV.........................
 
NDSGYLSKNKLD.SGIEPVLKNVEDQKNTSFSKVISNVKDANAYPQTVNE
NDSGYLSKNKLD.SGIEPVLKNVEDQKNTSFSKVISNVKDANAYPQTINE
SDSGYLSKNKLD.SGIEPVLKKVEDQKNTSFSKVISSVKDANTYPQTVNE
NDSGYFLKDKID.SDVQPDMKNTEG..NAIFPKI.SATKEIKLHPQTVNE
NKSEYLSRSKIDNSGIEPVIKNIRERKNIGFSEIMSPGREADTDPQSVNE
NKSENLSKNKIDNSGIEPVVKNVKGRKNTSFSKVIPTIREANINPQAVDK
FFSEHISDK.........................................
....LLPRGSVPRS.TSPYL.NC.GNKEIDLKRLNEPCSNTDSFTNTVD.
..TANIS...........................................
.............................................ENIDQ
.............................................EDTNR
............................................QSEQVP
 
DICVEELVTSSSPCKNKN.AA.IKLSISNSNNFEV..........GPPAF
DICVEELVTSSSPCKNKN.AA.IKLSISNSNNFEV..........GPPAF
GICVEELVTSSSPCKNKN.AA.IKLSISNCNNFEV..........GPPAF
E.CVQKLETNASPYANKN.IA.IDSAMLDLRNCKV..........GSPVF
DICVEKLATNSS.CKNKN.TA.IKVAISDSNNFNTIQKLNSDSNNSVPAY
DSCVLKLVTKFSPCKNKK.TA.AEVALSNSNNFET..........EPPAY
............................VMSCLKA..........QPPAF
NAHQEQSEFD.LPEDETNLTCLQETSLTAESQKSD..........LKQVF
..........................NRNEACTSL..........APLSF
LVPSQKPMPPL..................................EKHGF
LAATQKLVPSL..................................EKCGF
QKCSSVTSTGL..................FP..............KTVGF
 
RIASGKIVCVSHETIKKVKDIFTDSFS.KVIKENN.ENKSKICQ......
RIASGKIVCVSHETIKKVKDIFTDSFS.KVIKENN.ENKSKICQ......
STASGKIICVSHETIKKVKEIFTDSFG.KVIKENN.ENKSNICQ......
ITTHSQETV.......RMKEIFTDNCS.KIVEQNR.ESKPDTCQ......
STVNSKRVFVAHQT..KVTEGFTDNCS.MVTKQNT.KSKSDTCH......
STASDQIAFVSRET..TVRERFTDNCRNIYTKQNT.EPKSGTDQ......
TTASGKTVHISNEAVQKAREMFINNGD.KFLKPNI.ENKSENNQ......
STAKGKAVSVSESALASIRQMFQTDCD.ASVKSEI.ETKSGTNQ......
STASGKSVTVSHDSLQKARLMLSEAAND.VTVDTSKQEAAYITPAIRKTE
QTASGKRVSISHAALAKAKSLFQDCG.EDEGNISK.EQ............
QTASGKGVSISHEALRKAKTLLQDCG.EDEGKIRK.EQ............
QTASGNSVTVSEDSLSRARQLFAECD.AVSGTSS..NTESGLK..I....
 
...TKIMAGCYEALDDSED.ILHNSLDNDECSTHSHK.VFAD.IQSEEIL
...TKIMAGCYEALDDSED.ILHNSLDNDECSTHSHK.VFAD.IQSEEIL
...TKIVAGCYEALDDSED.IFHNSLDSDECSMHSHK.VFAD.IQSEEIL
...TS....CHKALDNSEDFICPSSSGDV.CINSPM.AIFYP..QSEQIL
...AEIVADYPKALDDSE.AIFPNSLGAIECSP.SHK.VFAD.IQSEQTS
...TKTVTDSHKALGNSEDVIFPNSPDNEEHNMHSHD.VSPD.IQSEPIL
...MKNVKDPSKILENKD..ISPKSFDGKKRNLSVNEGSFSNKIYSKK.A
...TAIAGSSSFTIHAGG.PGFATFLDTRKSEMNVAAPHFIN.GNGNLIE
AEKEQNTVDDSDRVHANT..FSFSTASGKKVNISGNSL.KQVR..AVCLS
..................................................
..................................................
...RECSPRVSPMLHPNT..SDSDTSQNATCKMD................
 
QHNQNMSG..LEKVSKISPCDVS.....LETSDICKCSIGKLHKSVSSAN
QHNQNMSG..LEKVSKISPCDVS.....LETSDICKCSIGKLHKSVSSTN
QHNQNMSG..LEQVSKMSPFDVS.....LETSDICKCSIGKLPKSVPSTN
QHNQSVSG..LKKAATPP...VS.....LETWDTCKSIRGS.PQEVHPSR
QLNQSMSG..LEKVSETPPCQIN.....SKTSDRCELPRGKLPKSVSYTN
.HDQSISG..LEKVSEIPLRHVD.....LKTSDRCKFNMGKHPRSVSSMN
QLENISAGIALEMDSEVSHCQIN.....SKTSDLYKSTIGKQPKGSS...
NNHQGANM..FADADSVPGFQMQCFEQKSKLLGHFPVPDKQMEQ.SGPSG
S.......DPKETSAALFNVEKSVFNEDVKDVSLLQP.NVTMPK......
.....................................MHSKMPVSDPPAR
.....................................IHFKMPFAEPPAR
...........NNHKTVQSEQVP.....QKC........SSVTSTGLFPK
 
TCGIFSTASGKSVQVSDASLQNARQVFSEIEDSTKQV.............
TCGIFSTASGKSVQVSDASLQNARQVFSEIEDSTKQV.............
TCGIFSTASGKSVQVSDASLQKARQVFSEIEDSTKQV.............
TYGFFSTASGKAVQVSDASLEKARQVFSEIDGDAKQL.............
ACGIFSTASGKSVQVSDAAIQKAREVFSKLEDSAKQL.............
ACGIFNTASGKSVQVSDSALQKARQVFSKSEDSAKQF.............
SVGIFCTANGKPVQVSDNSLKKARQVFSEIANDSEQL.............
NLGFFSTASGKPVQLSEESLKKARQLFSEMEGSHSSG.............
.AVSFSTASGKTVQLSDESLKKARVIFSEIDTC..PL.............
SCG.FRTASGKAATCSSEALQKAKALFSDISSNEDTG.............
SSG.FHTASGKATACSSEALQKAKALFSDISSNVETL.............
TVG.FQTASGNSVTVSEDSLSRARQLFAECDAVSGTSSNTESGLKIRECS
 
...FSKVLFKSNE.....H.SDQLTREENTAI..........RTPEHLIS
...FSKVLFKSNE.....H.SDQLTREENTAI..........RTPEHLIS
...FSKVLFKSNE.....H.SDQLTREENTTI..........HTPKHLIS
...ASMVSLEGNE.....K.SHHSVKRESSVV..........HNTHGVLS
...FPEVSLKDNEE....H.SEKFTNEENTVI..........YTSQNL..
...FSRVSFKSNEE....H.SDIFTRKENTMT..........HNPPNL..
...L...SIKGSES....H.PETLIGEENAML..........YAKINLPA
...LQDAHLLEDVEKSNNR.GEVFPREMQLLL.....PRGKENASTDK..
......MQQQTNES....T.VEEIVI.GGGMTKSKQMPLTTE........
....QADHADPEQ.....................................
....QTNHDDRKR.....................................
PRVSPMLHPNTSDS.DTSQNATCKMDNNHKTVQSEQVPQKCS........
 
.QKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEH
.QKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEH
SQKDFSHNVVNSSAFSGFSTASGKQVSISESSLHKVKGMLEEFDIIRTEH
.LRKTLPGNVSSFVFSGFSTAGGKLVTVSESALHKVKGMLEEFDLIRTEH
..........LSSAFSGFRTASGKQVPVSESALCKVKGMLEEFNLIRTES
..........LSSAFSGFSTASGKHVPVSESALCKVKGMFEEFDLIGTEY
.QKDYLSNMQNLYNNSGFNTASGKQVLISESALQKVKGMLVEFDLMRNEC
..........ISSPALGFSTASGKQVTISESAYQKAKAILKEADGFLSSE
...KVETTR.KNNGTFGFNTASGKQVSVSESALQKVKDIFQEFDDP..DN
.....EKTEN.KNVHCGFLTAGGAKVHISQKSISEAKNLLREFDS..QTP
.....DHIENEPKIHCGFSTAGGGKVHISQKSLLKAKNLFKEFDS..NTR
...SVTSTGL.FPKTVGFQTASGNSVTVSEDSLSRARQLFAECDA.....
 
SLHYSPTSRQNVSKILPR..VDKRNPEHCVNSEMEKTCSKEFKLSNNLNV
SLHYSPTSRQNVSKILPR..VDKRNPEHCVNSEMEKTCSKEFKLSNNLNV
SLHYSPTSRQNVSKILPC..VDKRTPEHCVNSEMEKACSKEFNLSNNFNV
TLQHSPTP.EDVSKIPPQPCLESRTPEYSVSSKLQKTYNDKSRSPSNYK.
CLQHSSTSRQDVSKMPPPSCIGKRTPEHSRNSKLDKACNKEFRLSSNCNN
SLQHSPTSRQDVSKILPVSCTDKRTPEHSVSSKMEKAYNKEFKLSNNYNI
LESIQDVTPKGLSPVLCI..EGSETPKHIVNSKSKEICNKELHFSNNCNV
LGVTNELCEIKESGQHAE....YLTGKVISESKTEKSCSEELDLKSIHPE
YEQNKSLVRLPVS.....SKIKESTPGTK.............RLVQTAG.
SGVSPSPVGS.......................AGKTRLEKMELSNVPKA
SGVSPSSVGA......................GANMSRTLKTELSNVAIA
..................................AIRNDIGGELSNGTLP
 
EGGSSENNHSIKVSPYLSQFQQDKQ.QLVLGTKVSLVENIHVLGKEQASP
EGGSSENNHSIKVSPYLSQFQQDKQ.QLVLGTKVSLVENIHVLGKEQASP
EGGSSENNHSIKVSPSLSQFKQDKQ.QLVLGTKVSLVENIHVLGKEQASP
ESGSSGNTQSLEVSPQLSQMERKQETQSVLGTKVSQ.RKTNILEKKQNLP
QSGSSENHHSIKVSPCPSQLKRDKP.QLLVGSKGSLVENIHPLGKEQALP
ESGSSENNHSIKVSSYLSEFKQDQQ.QSVLGTRVSHTDNIHLLGEKQTLP
EISSSENSRIIEVS..CAQFKQDMI.HPLLETKLTPAKEISFLKKGQVGL
KMKSLPSTHRVKITEYVPHSKRNSQ.SAPF.KNSFEQEETRFFRKGE.LN
.SSYKNDNLQCKAGNLRTFQDKQAGKKSLTYSEAAISPIITTVPGNQLTP
DESSLLCFQSFDI.....................................
DKSSLLCFQSFDI.....................................
.HGVQQPTLTSRADGDHLTHQRKDSKEEFH....................
 
KNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFMED
ENVKMEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFMED
ENVKMEIGKTEAFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFMED
QNIKIESNKMETFSDVSMKTN..VGEYYSKEPENYFETEAVEIAKAFMED
KNIKTEIGKAETFPNLPVKTNIEFCSTYSKDPENYFETETVEIAKAFMED
KYIKKEIGKTETFPDL.VKTNTEICSTDSKDPENYFETEAVEIAKAFMED
KDVDMES..SEAIDGLPVKRNLQVSSPNSKAQETSMEREAVEIAKAFMQD
LGIKTE..SESDLCSATSKAEI....NIFQTPKDYLKTEAVESAKAFMED
IQLVKVSTNTSALANK.TKPDLYV.ATAQNTPQNDFEIEAAESARAFLED
.........................NDCSETQQRFLAQEALDCTKALLED
.........................NDCSETQQAFLAQEALDCTKALLED
........QQERIRES.SRGDGSL.ATPSNLP...........APGGLAK
 
DELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILVGEPSIKR
DELTDSELPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILVGEPSIKR
GELTDSELPSHATHSLFTCPQNEEMVLSNSRIGKRRGEALISAGEPPIKR
DELTDSE.QTHAKCSLFACPQNE..ALLNSRTRKRGGMAGVAVGQPPIKR
GELTDSELLSHAKHFVFTCQNTKEMVLLNSRIGKRRGDALVSVGEPPIKR
GELTDSEFPSHAKHSPFTCQKNEETVLSNSRIEKRRGDALVTVGEPPIKR
DEFTDSELPHNAKKSFFTYKNNEERILTNSRFGKRRMEERASYGEPPIKR
D.LSDSGVQVKSAQSFGKMSDN....FQNKPFGKRHLDEKDSHGEPPIKR
DDLTDMGSAAHETYLYLNQT.......SNTRTGKRSRTEGPTPGEPPIKR
ESLLLDGDLQPAAD.............DRKRKGKRLVDDPHMTEQPPLKR
ESLLLDDDPRPADRS............ADDRKRKRLVEDSDLTNHPPLKR
KSMVDTRNRQSNQQ.............RNKGTGSR......GTGQKPYKP
 
NLLNEFDRIIE.NQE..KS..LKASKSTPDGTIKDRRLFMHHVSLEPITC
NLLNEFDRIIE.NQE..KS..LKASKSTPDGTIKDRRLFMHHVSLEPITC
NLLNEFDRIIE.NQE..KS..LKPSKSTPDGTIKDRRLFMHHVSLEPITC
SLLNEFDRIIE.SKG..KS..LTPSKSTPDGTIKDRRLFTHHMSLEPVTC
NLLNEFDRIIK.NQE..TS..LKASKSTPDGILKDRSLFMHHISLEPISC
NLLNEFDRTIE.NQG..KS..LKASKSTPDGTKNRKSKITHHWKKAPMEC
KLLYEFDRAVE.NQA..KS..LKPSKSSPDGTMKDRRKLMHHISLKPVTC
QLLLEFEKMK..IPP..KS..VKPLKSTPDGIFKDRRKFMYHVPLKPVTC
RLLPEFDRTTD.TRQ..QTGILKPLISTPD.MMRDRRRFLYTLPLKPSTC
RLLEEFDRTDGGSRG..SA..LNPEKCSPNGIMGDRRVLKCSVSFQPNIT
RLLEEFDRTDDGSRG..ST..LIPEKCSPNGIMKDRRVFNYNRSFCPTIT
P......RRVD.DKGSTSAAGLIPRCSNPTVVLNDRTKQCKAR.....QS
 
VPFRTTKERQEIQNPNFTAPGQEFL............SKSHLYEHLTLEK
VPFRTTKERQEIQNPNFTAPGQEFL............SKSHLYEHLTLEK
VPFCTTKERQEIQNPNFTAPGQEFL............SKSHLYEHLTLEK
GPFCSSKERQETQSPHVTSPAQGLQ............SKEHPSRHSAVGK
GPFRTTEERQEIQNPNFTAPGQEFL............PKSHFYEHLASEK
KECCITTERQEIQTPNFTAPGQEFL............SKSHFYEHLTLGK
DPFSTAKEWRQMRYPNFTAPGQELA............SKYHFLKHQTLEN
QPLGTTKERQEVRNPTLTLPDQDLKG.........FKSIPAVFQHCALRQ
NPESALRQVTCIPTQAHLHSKVKI...................FHQSLPI
TPHRSGTNYVETSLPNTTPTKVSALRDSNEARLQKSNFIPPFIKNVKLDT
TPHG.GENFKETRLQITTPTKASTLSDINEAPLQESTFIPPFLKNTRSGS
SPP...............................................
 
SSSNLAVS..GHPFYQVSATRNEKMRHLITTGRPTKVFVPPFKTKSHF..
SSSNLAVS..GHPFYQVSATRNEKMRHLVTTGRPTKVFVPPFKTKSHF..
SSSNLAVS..GHPFYQVSATRNEKMRHLITTGKPTKVFIPPFKTKSHF..
SSSNPTVS..........ALRSERTRHSV.SDKSTKVFVPPFKVKSRF..
SSSNLSVS..RQPFCMVPATGNEKRRHLIAPGKPVKVFVPPFKTKSHF..
SSSNLSIS..GQPLCKVPDPRNEKRRHSITIGKPMKVFVPPFKTKSHI..
SSHNLLLQ...SPSYKDSSTDNGKVKSISVRGKPAKVFVPPFKTNSNSST
SSSGASGL..FTP.HKAVAKDSEETRSLCKSGKAVKTFVPPFKTKLTL..
KSPDVASD..STSKSYSPTAAKETINCSSASKIPAKKFVPPFKKTVATLA
PNSKTL....SSTSTFVPPFKKSRNSSKTEEEEPKHHFIPPFTNPCAT..
PKGTVLKDNITTPSAPIPPFKKLKKSSKTEEED.KHHFLTPITNQPAA..
....................TSLSTSSHCVSDGSLHRAGPSVKSCPD...
 
HRVEQCV.R..NINLE.......ENRQK.QNIDGHGSDDSKNK.INDNEI
HRVEQCV.R..NINLE.......ENRQK.QNIDGHGSDDSKNK.INDNEI
HRDEQCV.R..NINLE.......ENKQK.QNIDGHGSGDSKNK.INDNEI
HRDEHFDSK..NVNLE.......GKNQKSAD......GVSE.D.GNDSDF
HRDEQCISK..NTKLE.......KNKQNSKDIDELGSGDSEKN.INDSGI
HRDEQFVGK..NTNLE.......ENKQQ.KNIDEHGSGDSENN.VNNCEI
ATDDEFVRK..RLKVKVKEYT.PENEKQ.KYGDAHNSGDSENN.EN....
STGEQGGSK..RCHSPIRNSVMEERELN.QIPVEQNSAEARDH..QSCIL
..DNQSNSVQNGSSDGLIESIV.....YPKEDKVETICSSKDQ.FD....
SSTKKHTAG..VTG..........NKPA.EDVPRVTLAETASGEPVMSP.
PSSKKCTVS..LTS..........NKPA.EDSPQVALAETGNDELVMSPR
.................................QDATNQSQSQ.LE....
 
HQFNKNNSNQAAA..VTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQR
HQFNKNNSNQAAA..VTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQR
HQFNKNNSNQAAT..VIFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQR
PQFNK.....................DLMSSLQNARDLQDIRIKNKERHH
HQLKKNNSNQAAT..IIFTKNEKEPLDLITNLQNARDIQDMRIKKKQRQH
HQ.........TT..ILFTK......DSITNLQNARDIQDMRIRKKQRQC
YLSDKDNSNQATT..DIFKECGNLHLEMIENLQHAREMQDMRIKKKQTQK
HA.........AV..TDIENDNLVTSNMMANLHCARDLQEMRIKKKYRQN
.....................DSDILQMTSNLRCSKDLQEMRIRKKLRQK
.....GSEDPAAEAACMEDTLSRDLFQHLHNVELARDMQDMRIRKKKRQT
RQAARGSENPAAEAECVRGTLSRVPFQHLHHFQLARDMQDMRIRKKKRQT
...........AT.....PTIAEGGCSFVARWAEARRAQQQRIDAKRKKV
 
VFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKI
VFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYMYGVSKHCIKI
IFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYMYGVSKHCIKI
LCPQPGSLYLTKSSTLPRISLQAAVGDSVPSACSPKQLYMYGVSKACISV
IFPQPGSLYLAKTSTLPRISLREAVEGRVPSACSHKQLYMYGVSKHCVKI
IFPQPGSLYLAKTSTMPRIPLREAVEGRIPSACSHKQLYMYGVSKHCVKI
IHPQAGSLYLRKTSTLPRSSLRVVVEGKVPSTYSSKQLYMYGITKQCLKI
ISPQPGSLYVTKTSARNRISLKTAVEEETPSFHSTEKLYTYGVSKHCIQV
IKPHPGSLYRLKMSHVKRISLQSAVAERCPTLYSREQLYRYGIVKNHIGV
ILPLPGSLFLKKSSGVTRIPLKSAVNGKPPARYTPKQLYGLGVPLNVLEI
IRPLPGSLFQKKSSGVARIPFKAAVNGKPPARYTAKPLCGLGVPLNVLEI
IKPELGSLWRSRKE.QDRISLGEFVNHQYPCSMSDSELFGHGILSSTLSV
 
NSKNAESFQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYR
NSKNAESFQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYR
NSKNAESFQFYTQDYFGKESLWAGKGIQLADGGWLIPSNDGKAGKEEFYR
NSKNAEYFQFAIEDHFGKEALCAGKGFRLADGGWLIPSDDGKAGKEEFYR
NSKNAESFQFHAQDYFGKEGLWSGEGIQLADGGWLIPSNDGKIGKEEFYR
NSKNAEAFQFHTQDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYR
NSKNSESFKFHSEDYFSKEHLLDGNGIQLADGGWLIPTDEGKLGKEEFYR
NSTNAESFQFLIEEFFSKEYLLAGNGIQLADGGWLIPTDEGKAGKKEFYR
SSENALSFQFHCSNYFTKELLLSGNGVQLADGGWLIPTEQGNAGKEEIYR
TSETAGSFRFSLQQFVKLESLTDKGGIQLADGGWLIPRNDGTAGKEEFYR
TSETAESFRFSLQHFVKLESLIDKGGIQLADGGWLIPTNDGTAGKEEFYR
RPSNAEGYEFAGEDHFSPSCLESDRGIPLDDGGRLVLSPNGLAGKKEFYS
 
ALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPKEFANRCLSPERV
ALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPKEFANRCLSPERV
ALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPKEFANRCLSPERV
ALCDTPGVDPKLISSVWVSNHYRWIVWKLAAMEFAFPKEFANRCLNPERV
ALCDTPGVDPNCISRVWVYNHYRWIIWKLAAMEFAFPKEFANRCLSPERV
ALCDTPGVDPKLISRVWVYNHYRWIIWKLAAMEFAFPKKFANRCLNPERV
ALCDTPGVDPKLITKTWVYNHYRWIIWKLAAMEFTFPKEFASRCLTPEWV
ALCDTPGVDPKLITEAWVYNHYRWIVWKLAAMEVCFPHKFANRCLTPETV
AFCDTPGVDPKLISAEWVHNHYRWIVWKLAAMEVRFPKTFACRCLTPERV
ALCDTTGVDPKLISEEWVYNHYRWIVWKQASMERSFPEQLGSLCLTPEQV
ALCDTPGVDPKLMSEEWVYNHYRWIVWKQASMERSFPEEMGSLCLTPEQV
ALLDTPGVDPKLLKEEWVFNHYKWIIWKAAAMEVAYPLQLGGRFLTPNWV
 
LLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANISE
LLQLKYRYDMEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANISE
LLQLKYRYDMEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANISE
LLQLKYRYDVEIDNSSRSALKKILERDDTAAKTLVLCVSDIISLSTNVSE
LLQLKYRYDVEIDKSRRSAIKKIMERDDTAAKTLVLCISEIISSSADISE
LLQLKYRYDVEIDRSKRSAIKKIMERDDTAAKTLVLCVSEIISLSTDISE
LLQLKYRYDIEIDESRRSAIKKIMERDETPAKTLVLCVSEIISSGTNISI
LLQLKYRYDLEIDKSKRSAIKKITERDDAAGKTLVLCVSKVLSLNTAVSP
LLQLKYRYDVEIDKSQRSAIKKIMERDDSPAKTLVLCIAKIISQGTRLPN
LLQLKYRYDIEVDQSRRPALRKIMERDDTAAKTLILCVCGVVSRGSSPQK
LLQLKYRYDIEVDHSRRPALRKIMEKDDTAAKTLVLCVCGVVFRGSSPKN
LLQLKYRYDREIDHSQRPALRKILERDDAASRRMVLCVAAIGNTGSSAGH
 
TSSNKTSS....ADT.QK.VAIIELTDGWYAVKAQLDPPLLAVLKNGRLT
TSSNKTSS....ADT.QK.VAIIELTDGWYAVKAQLDPPLLAVLKNGRLT
TSSNKTSS....ADT.QK.VAIIELTDGWYAIKAQLDPPLLAILKNGRLT
TSGSKASS....EDS.NK.VDTIELTDGWYAVKAQLDPPLLALVKSGRLT
TSSSKTSS....VGT.KK.VGIIELTDGWYAIKAQLDPPLLALVKNGRLT
PSSNKTSS....VDT.TK.VAVVQLTDGWYAIKAQVDPPLSALLKNGRLT
TANSKNNS....VET.KKESAVIEVTDGWYAIKALLDSSLLAILQKGKLT
..SNSNN....NTEGEKA.AAIIEVTDGWYGIRALLDPPLKAFLHRRRLT
ACSNKTE..P..ADS.KESSAVIEVTDSWYGIKVLLDPCLTALLHKGRLF
QSLGGVAAPSSDPQVENP.FAVVWLTDGWYSIKAQLDGPLTSMLNRGRLP
KSFGDISTPGADPKVENP.CAVVWLTDGWYSIKAQLDGPLTSMLHRGRLP
DGKGAEQRKS..LQA..VSHPTLELTDGWYSIPAAIDPPLANHVRSGRIV
 
VGQKIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFP
VGQKIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFP
VGQKIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFP
VGQKIITQGAELVGSPDACAPLEAPDSLRLKISANSTRPARWHSKLGFFH
VGQKITIHGAELVGSPDACTPLEAPESLMLKISANSTRPACWYTKLGFSP
VGQKIVIHGAELVGSPDACTPLEAPESLMLKISANSTRPACWYAKLGFSP
TGQKIITHGAELIGSQEACTPLEAPESLMLKLSANSTRPARWYAKLGFFS
VGQKIIVHGAELIGSPNGCTPLEAPDSLMLKIAANSTRCARWYTKLGFHR
IGQKLIVHGAELIGSDDACSPLEAPESLMLKIAANSTRPVRWHTKLGYFK
VGGKLIIHGAQLVGSQDACSPLEAPESIMLKIFANSSRRARWDSKLGFYR
VGGKLIIHGAQLVGSENACSPLEAPVSLMLKICANSSRPARWDSKLGFHR
CGTKLCISGAELVGAQDACSPLEIPEGLKLKITANSTRRARYDARLGLQA
 
DPRPFPLPLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNERE
DPRPFPLPLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNERE
DPRPFPLPLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNERE
DPRPFPLPLSSLFSDGGNVGCVDVIVQRVYPLQWVEKTVSGSYIFRNERE
DPRPFPLPLSSLFSDGGNVGCVDVVVQRAYPIQWMERTPSGLCIFRNERE
DPRPLPLPLSSLFSDGGNVGCVDIIIQRAYPIQWMEKTSTGLYIFRNERE
DPRPFPLPLSSLFSEGGNVGCVDIVVQRVYPTQWMEKTLSGSYIFRNERA
DPRPFPLPLSSLYSEGGTVGCIDVVVQRTYPIQWMEKTSAGSYVFRNSRA
DPRPFCLHLSSLLSEGGVVGCVDVVIQRIYPMQWMEKMANGLYVFRNDRA
DPRPFLLPVSSLYNSGGPVGCVDIIILRSYPTLWMERKPEGGTVFRSGRA
DPRPFLLPVSSLYSSGGPVGCVDIIILRSYPILWMERKPEGGTVFRSGRA
DPRPFPLPMTSLHPEGGTIGCLDVLILRTYPMQFMEKLPEGGSVFRNAKE
 
EEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENT.TKPYL......PSRA
EEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENT.TKPYL......PSRA
EEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENT.TKPYL......PSRA
EEKEALRFAEAQQKKLEALFTKVHTELKEHEEDI.AQRRV......LSRA
EEKEATKYAEIQQKKLEVLFNKIQAEFEKNDENI.TKQCI......PSCA
EEKEATKYAEAQQKKLEALFTKIQAEFEDHEENV.TEQCI......PSRA
EEKEALKYAECQQKKLEALLTKIQAEFEKHEENS.ATQHR......QSHI
EEREAAKHAEDQQKKLEALFAKIQAEFEKHEERN.CRRAP......RSRI
EEREAEKHSANQQKKLEMLFSKIQAEFEQREVTCNRRKGL......RRRS
EEKEARRYNVHKEKAMEILFDKIQAEFEKEERDN.RKPRS......RRRT
EEKEARRYNIHKEKAMEILFDKIKAEFEKEEKGN.RKPQ.......CRRT
EAKAAALHASRKQNKMEQLFTQIQKQFEAKQATK.GQGGKRRRSLPSSRS
 
LTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDK
LTRQQVRALQDGAELYEAVKNAADPAFSQGYFSEEQLRALNNHRQMLNDK
LTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDK
LTRQQVHALQDGAELYAAVQDASDPEHLETCFSEEQLRALNNYRQMLSDK
LTRQQICALQDGAELYEAVTNAPDPSDLEGYFSEEQLRALNNHRQMLNDK
LTRQQVRALQDGAELYEAVKNAPDPSYLEGYFSEEQLRALNNHRQMLNDK
LTRQQVRALQDGADLYEAVKNAPDPAYVEGCFSKEQLRTLNHHRQILNDK
VTRQQIHNLQDGAELYEAIQNAADPSYMEGYLSEDQLKALNAHKQLMNDK
LNAQQMQTLQDGAEIYEAIQNESDPGYLESYLSAEQLKALNHHRQLLNDK
IGDQDIKSLQDGEELYEAVGD..DPAYLEAHLTEQQAETLQNYKRLLIEK
INGQNITSLQDGEELYEAVGD..DPAFLEAHLTEKQVEVLQNYKRLVMEK
RNPVEVEKLQSGEELFEAMEAAIDPAAFESVLSERQCSTLHAYRRLQNEV
 
KQAQIQLEIRKAMESAEQKEQGLS.RDVTTVWKLRIVSYSK..KEKD.SV
KQAQIQLEIRKAMESAEQKEQGLS.RDVTTVWKLRIVSYSK..KEKD.SV
KQAQIQLEIRKAMESAEQKEQGLS.RDVTTVWKLRIVSYSK..KEKD.SV
KQARIQSEFRKALEAAEK.EEGLS.RDVSTVWKLRVTSYKK..REK..SA
KQAQIQLEFKKAMESAEQGEQILP.RDVTTVWKLRIISYRK..KEKD.SV
KQAQIQVELRKAMESAEQGEQILP.RDVTPVWKLRIMSYKR..KEKD.SV
KQEQLQAEFRKAIAAAELEEHGLAKRDVTTVWKLRVVNYKK..HEKD.SV
KQTRIREEFKKAVESAEQEKHGFSKRDVSTVWKLFVIDYRK..QEKHRGV
KQALIQAEFRKAIECSEQDANGCTRRDVTPVWKLRIADYRN..YETDAAY
KQAELQDRYRRAVETAEDGTGSCPKRDVAPVWRLSIADFME..KPGS.VY
QQAELQDRYRRAVESAEDGVGGCPKRDVAPVWRLCIADSMG..HSG..LY
KQADLQAAFNRSL..AQQNKEGKFERTVVPLMKVRVGDYNAPINKGQQTT
 
ILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQY
ILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQY
ILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAVTKKTQY
LLSIWRPSSDLPSLLTEGQRYRIYHLSVSKSKNKFEWPSIQLTATKRTQY
TLSIWRPSPDLYSLLIEGKRYRIYHLAASQSKSKSGKANTQLTATKKTQY
ILNIWRPSSELYSLLTEGKRYRIYHLTASKSKSKYERANIQLTATKKTQY
ILSIWRPLSDIYALLKEGNRYRIYNLATSPSKSKSDRAHIRLTATKKTQY
ILSIWRPLLDVCSLLKEGSRYRICQLSTSQSKGRSDSTNVQLSATKKTRY
ILNIWRPLPDVLSLLKEGCRYKMYHLAASTSKGKSLAADLQLTATKKTRF
QLNIWRPPSELQSLLKEGCRYKVYNLTTTDSKKQGGNTTVQLSGTKKTQF
QLSLWRPPSELQALLKEGCRYKVYNLTTLDSKKQGGNATVQLTATKKTQF
FLTLWRPPDDLVTELVEGKRFRISSVATSAGRNMPGMCPVQLASTRATRY
 
QQLPVSDEILFQIYQPREPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKT
QQLPVSDEILFQVYQPREPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKT
QQLPVSDEILFQVYQPREPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKT
QQLPVSSETLLQLYQPRELLPFSKLSDPAFQPPCSEVDVVGVVVSVVKPI
QQLPASDEILSQVYQPREPLYFNKLLDPDFQPPCSEVDLIGFVVSVVKKI
QQLPASDEILLQIYQPREPLHFNKLLDSDFQPPCSEVDLIGFVVSVVKKI
QQLPVSHEALSQVYQPREAVPLDKLMEPSFRPLCAEVDVVGVVISVTKKP
LQLSVSQKMLQQIFFPRKALKFTSLLDPSYQPPCAEVDVVGVVISISR.T
QQLQPSESILEQIYSPREVTDFSRFQEPLFSAPYAEVDLVGLIISIYKKT
EDLQASEELLSTYFQPRVSATFIDLQDPEFHSLCGEVDLTGYVISIIDGQ
EHLQGSEEWLSKHFQPRVATNFVRLQDPEFNPLCSEVDLTGYVITIIDGQ
EELPAASLKLQRSYIPRAAASMQWLGRGYTQAAYGELDAVGIVVSLDEPS
 
GLAP......FVYLSDECYNLLAIKFWIDLN....EDIIKPHMLIAASNL
GLAP......FVYLSDECYNLLAIKFWIDLN....EDIIKPHMLIAASNL
GLAP......FIYLSDECYNLLAIKFWIDLN....EDIIKPHMLIAASNL
GLAP......LVYLSDECLHLLVVKFGIDLN....ED.IKPRVLIAASNL
GLAP......VVYLSDECHNLLAIKFWTDFN....EDIIKPYTLIAASNL
GIVP......LVYLSDECHNLLAIKFWIDLN....EDIIKPHMLIAASNL
GVAP......LVYLSDEYYNLLAVKFWIDLN....EDVIKLHTLIAASNL
GFSN......MVYLSDESYNLVAIKIWADLRHFAIEDIVVRCSFIAASNL
GAAP......VVYISDESHNIVALKFWTDLGQLGLEEITKPRTYISASNL
GFSP......AFYLTDGKQNFVKVRCFSSFAQSGLEDVIKPSVLLALSNL
GFSP......AFYLADGKQNFVKVRCFSSFAQSGLEDVIKPRVLLALSNL
RQHPGSSQYHAVYLADQDAAVMVIKFWTSPSALNLDDMLKPGSFISVSNL
 
QWRPESK....SGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDI
QWRPESK....SGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDI
QWRPESK....SGLPTLFAGDFSVFSASPKEGHFQETFNKMKNIVENIDI
QWRPEST....SRVPTLFAGNFSVFSASPKEAHFQERVTNMKHAIENIDT
QWRPEAK....SGIPTLFAGDFSRFSASPKEEHFQETFHKMKNTVENIGM
QWRPGCK....LGIPTLFAGDFSMFSASPKEGHFQETFHKMKNTVENIDT
QWKTESR....AGIPMLFAGEFSVFSASPKQSHFQERFNKLKNSVENIDL
QWQSEFR....SEIPVLLAGDLSAFSASPKENHLQEKFNELRRMIENVDS
RWRSDCI....EGIPTLYVGDLANISSNPKESHLQRAIQKLKLSVQNVQD
QLRGQAT....SPTPVLYAGDLTVFSTNPKEVHLQESFSQLKTLVQGQEN
QLRGQST....SPTPVVYAGDLTVFSTNPKEVHLQESFSQLKTLVQGQEN
QYRSISSTLSAVALPTATASDYTVFTPNPKAGYLQVALSQLRGAIKDVPK
 
LCNEAENKLMHILHAND.PKWSTPTKDCTSGPYTAQIIP....GTGN.K.
LCNEAEKKLMHILHAND.PKWSTPTKDCPSGPYAAQIIS....DTGN.K.
LCNEAENKLMHILHAND.PKWSTPIKDWTSESYTAQIIP....STGN.K.
FYKEAEKKLIQVLKGDS.PKWSTPNKDPTREPYPASTCSASDLASGG.Q.
FYNDAENKLVHILNAND.PKLSTPTKDYASEPHTAQIVL....GIGN.K.
FCEDAKNKLIRLLNASN.PKWSTPTKDCTSAPPTAQTVL....GSGN.K.
FCDGAEKKLSHLLDTHN.SKQPNAVREYNLDSPSPQAKL....GLGP...
FCSDAESKLMNLLQRNC.SLTPILPKRCGLECSSPSCNS....GLYAED.
FWNSSQTALMKTLQINS.T....DTTECSKNPTTPTWKSD..........
FFVHAQEKLSELTQSYGLSTVLSPAGQAQTPY.STDD......KGGD...
FFVHAEEKLSQLM.SDGLSAIASPAGQIQTPA.STVK......RRGD...
CLELMQRKVQQLKDAP.S.QPAYPGSTPRNHPYTAGRERVTTPLAGLSRA
 
..............................LLMSSPNCEIYYQSPLSLCM
..............................LLMSSPNCEIYYQSPLSLCM
..............................LLISSPNCELYYQSPLSLCM
..............................LPRSSPTDQQSYRSPLSCCT
..............................FLMSSPNNEMNYQSPLSLCK
..............................FPLSSPSSEMNYQSPLSLCK
................................MISP....FHREPNHHC.
..............................RSSISSKIETKHPSPLSAST
...................................VSARSGYLTPLHHS.
..........................................RKAKVSCH
...........................................MTDVTCQ
RSGIQSSPPTSVTSQGQPYQLMTVRSCPKNFPKTSQPTRDENLNPRIQVA
 
AKRKSVST..............PVSAQMTSKS.CKGEKEIDDQKNCKKRR
AKRKSVST..............PVSAQMTSKS.CKGEKEIDDQKNCKKRR
AKRKSVST..............PISAQITSKS.CKGEKEIDDQKNCKRRR
PTGKSTPL..............AHSAWMAAKS.CSGENEIEDPKTCRKKR
PKEKSVPI..............PGSTQMTSKSYCKEEKEMDDPKTCKKRR
LNEKSVCT..............PVSAQVTSKSCCKGEKETDDPKSCKKRR
PEGNSGAT..............ISSVKISPTSDCRGDRKMDDPKICKKRR
PNTK..LF..............PQGSAITPSSAVSSEN...HPRNSKKRK
GKRLLNSV..............HTSDPQTENPGCSKEI...QLKTCKKRK
QQGRSLKF..............STPVNRASAANSSGDR...NPSTVKKRK
QPGRSHRF..............STPINRNSTAHSSAER...NPSTIKKRK
GSTPSHSHPGTSRVSTNPTPRTPCQSQVSAISGVDVSPRV.LAQHVELER
 
ALDFLSRLPLPPPVSPIC.TFVSPAAQKAFQPPRSCGTKYETPIKKKELN
ALDFLSRLPLPPPVSPIC.TFVSPAAQKAFQPPRSCGTKYETPIKKKELN
ALDFLSRLPLPPPVSPIC.TFVSPAAQKAFQPPRSCGTKNETPIKKKELN
ALDLLSRLPLPPPLSPVC.TFVSPAAQKAFQPPRSCGTKYPTPLKKEGPS
ALDFLSRVPLPPSVSPIC.TFVSPAAQKAFQPPRSCGTKYETLMK.KELN
ALDFLSRLPVPPPVSPIC.TFVSQAAQKAFQPPRSCGTKYETPMKKNELN
SLDFLSRLPLPPPISPIR.TFVSPAAQKAFQPPRSCGNKYNVPVKKNTSN
AVDFLSCIPAPPPLTPLC.SIISPSLKKAFQPPRRLGSQHSKLSKETNPN
ALDFLNRIPSPPPVTPVR.PFVSPSLQKAFRPPRSCSVQKLGPETKGNTE
ALDYLSRIPSPPPLSFLS.SVSSPCVKKTFIPPRRS....ETPGTLKSVK
ALDYLSHIPSPPPLSCLS.TLSSPSVKKIFIPPRRT....EIPGTLKTVK
RSQLLSRIPSPPPLSPLPYPAASPALKRGFKIPSPLVRGSQKPDPEKSLR
 
SPQ.MTPFKKFNE.ISLLESNSIADEELALINTQALLSGSTGEKQFISVS
SPQ.MTPFKKFNE.ISLLESNSIADEELALINTQALLSGSTGEKQFISVS
SPQ.MTPFKKFNE.ISLLESNSIADEELALINTQALLSGSTGEKQFISVS
SPWSRAPFQKASG.VSLLDCDSVADEELALLSTQALVPHSVGGSEQVFPS
SPQ.MTP.RKFND.LSLLESDSIADEELAMINTQALLLGSPGEHQLVSVS
SPQ.MTPRKKFND.ISLLESDSIADEELALINTQALLSGSAGGNQLTSIS
SPQ.MT.IKTLSG.TTMAENDLIADEELALINTQALLPNSSE
AGC.VTPSRKLREAVQLPDNDLVADEELAMINTQALINTVPEEKKMDYVN
NVQ.GTTPECTKD.LAKLEGEFVADEELAMINTQALLLGLEEEKKKTEQK
.....TPT.QKPP.NALVDDQWVNDEELAMIDTQALHVG
.....TPN.QKPS.NTPVDDQWVNDEELAMIDTQALHVG
KRLRDELEEQDDKDSEQQCKQQSDIGFDEGENTYKKQKTDSHVDDSNQKE
 
.ESTRTAPTSSEDYLR.LKRRCTTSLI.............KEQESSQAST
.ESTRTAPTSSEDYLR.LKRRCTTSLI.............KEQESAQAST
.ESTRTTPTSSKDYLR.LKRRCTTSLI.............KEQESSHSDK
.DSTRTEGPSASTEAR.PANRSKRESL.............RDCRDDSDGK
.DSTRTAPTSSKDYLG.LKRHSTAPGV.............RGPESPQACT
.KSTRTVPTSPKDYVG.LKRPYTTSVI.............KERENSPART
EDSTRATNLSGDTRATNLSRDMRAPNLSGDLSSKNSSRSAKEANSSLKSS
..TSRTAGKMTAHESP..IENASPVPA.............QEQQTEEALN
VKSQTDNHSNLDDTIEEYEDRGEDDFGDDLGLSASGLRELEMSWSQSEPL
 
EECEKNKQDTITTKKYI
EECEKNKQDTITTKKYI
EECENNKQDTITTKKYEH.....LQR
LAAET.VPDYS
RKREPRVQNTSDLKRTSLR....LQRQQTQK
EEQETNIPDTSAIKNRSKR....LQRRQKPK
SEGADALQKDTEEPEGSLSIRRVLQRRKSRKCY
IPVGNSEKSYLCLRKRKRK
PEPAARDRTLKMNTCQAEEGCPSRSKDSLDEDKDALPTDMSLEKDNHRIS
 
GLQDEKHVASGIDKAVEGTVEACKDVVGVHETERDVVPCTKPVQPEQLAD
 
HTGVNCDDPTHPTTNNSNLTMANASETTSICKVEDSGALILPPHCETIGE
 
NVEANGAGIMENVKQVEDIPDQVSANLNNPESMKETHAAENHRNSEGSAS
 
SNQTKDATKEDNSQGSILSQQSRGNDSSQNSTPVDGSQDSSKQDKSSGPS
 
SPKGNKRKCLSLQRKKAVPEEAGAVIEILEDDNPPLLKRSSRLRLQQKKS
 
YKF
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