| |
| Hsap | M.S.RESD..VEAQ.QSHGSSACSQPHG............SVT....... |
| Mmus | MKSHHQSH..SSTSSKAHDSASCSQSQG............GFS....... |
| Cfam | M.S.RETD..VECQ.QSHGSGACSQSQG............TFS....... |
| Btau | M.S.RETN..VERQ.QPRGSAS.PQSQG............GFS....... |
| Lafr | M.S.READ..MDCQ.QSQDGTS.SQSQGATSSQSATSSQPAFSSSWQSHS |
| Mdom | M.S.RETG..GDSQ.QS................................. |
| Oana | M.S.RESR..GESQ.QS................................. |
| Ggal | M.S.RETR..SDAQ.PS................................. |
| Xlav | MMS.RDTK..TESQ.Q.................................. |
| Drer | M.S.EEAGPSGESQ.S.................................. |
| Spur | M.Y.ESDM..STAS.AG................................. |
| Cint | M.E.DTND..ERPK.EKNASSSV........................... |
| Dmel | M.A.RDTQ..G....................................... |
| |
| ...QSQ.GSSSQSQGI......SSSSTSTMPNSSQSSHSSSGTLSSLETV |
| ...QPQ.GTPSQLHELSQYQGSSSSSTGTVPSSSQSSHSSSGTLSSLETV |
| ...QSQ.GISSQTHGSSSHSQGTSSSTSTAPTSSQSSHSSSGTLSSLDTV |
| ...QSQ.GPSSQPHSS......SSQSQGT...SSQSSHSSSGTLSSLDTV |
| SSLQSP.GLSSQPHGSSQSQNTSGSSSGTVHTSSQSSHSSSGTLSSVDTV |
| ...QS....TSQSQNA......SSSSSGA..SHSQSSHSSSGTISSLDTV |
| ...QS....ASQSQNA......SSSSSSATHTSSQSSYSSSGTLSSLDTI |
| ...QG....TQPSQGG......TSSSSSASQGASQSS.SSSGTLSSLDTV |
| ............SQGT.....SSSSSSSAPQSYSQSS.S.SGTLSSLDTV |
| ...QTQ..SQTQSQPA.......SSSSSAPTSSSQGSSSGSGTLSSVDTV |
| ...........GSASS.......SSIEPNSTSSASASLSSAGTLSSMETI |
| ...ESDKEKMRSPASL.......PASQEKVSSSSGTGTSSGNTVSSADTV |
| .......................................TQGTQSQASNI |
| |
| STQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVN..DNYW |
| STQELCSIPEDQEPE.....EPGPAPWARLWALQDGFSNLDCVN..DNYW |
| STQELCSIPEDQEPE.....EPVPAPWARLWALQDGFPNLECVN..DNYW |
| STQELYSIPEDQEPE.....EPVPAPWARLWALQDGFSNLDCIN..DSYW |
| STQELYSIPEDQEPE.....EPIPAPWARLWALQDGFSNLECVN..DNYW |
| PTQDLPSIPEDEEPE.....ELDPQPWGRLWALDDGFSNLDCVE..NDYW |
| PTQDLPSIPEDQEPE.....EPAPAAWGQLWALQDGFSNLECVL..DDYW |
| PTQELPSIPEDPEPD.....ELVPQPWGRLFALGKGFSNWDCVN..DEYW |
| PVQDLASIPEDPEID.....EDIPQPWGRLWALGKGFLNHDCLH..EEYV |
| PVQELQSIPEDEE.......EVQPQVWGRTIPLKQGFSVLNCTE..NQYS |
| PTQEVAEGDFDFA.......EERVVVWGRLYPVGKCFSSIDFLDTKDEYI |
| PTQEITDSQGVEL.......EP...VWGVLHSMQPEFYSLNLRD..EQYT |
| WTQ.V.ESQPME...........KIVWGRLYGKNIKIKSLDLNN..DEFT |
| |
| FGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHS |
| FGRDKSCEYCFDGPLLRRTDKYRTYSKKHFRIFREMGPKNCYIVYIEDHS |
| FGRDRSCEYCFDEPLLKRTDKYRTYSKKHFRIFREMGPKNSYIAYIEDHS |
| FGRDRNCEYCFDEPLLKSTDKYRTYSKKHFRIFREMGPKNSYIAYIEDHS |
| FGRDRSCEYCFDEPLLKRTDKYRTYSKKHFRIFREMGPKNSYIAYIEDHS |
| FGRDRRCEYSFDKPGLKKTDKYRTYSKKHFRIFREKGPKNSYIAYIEDHS |
| FGRDKSCDYSFDKPELNRTEKYKTYSKKHFRIFRELGPKSSYITYIEDHS |
| FGRDKSCDYSFSKLGLSETGFYQNYSKKHFRIFREMGPKNSYVAYIEDHS |
| FGRDKKCDYTFDIPVLNQTDRYKTYSKRHFRIFQELGHGHSRVAYIEDLS |
| FGRDKRCDYSFSNSILKKSPYFNTYSKKHFRIFRD.....ENLVYLEDLS |
| FGRDPSCDVCYNGPEISKNPCYQTLSKTHFRIFKE.SNDNCNFYFIEDKS |
| FGRANSCDYCFDIKTIKSTSRYKHYSKRHFAIRRVKLEDETYQVFIEDFG |
| AGRGEANDLILTLNDLPEKILTR.ISKVHFIIKRANCELTNPV.YIQDLS |
| |
| G.NGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYP |
| G.NGTFVNTELIGKGKRCPLSNNSEIALSLCRNKVFVFFDLTVDDQSVYP |
| G.NGTFVNRELVGKGRRLPLNNNSEIALSVWSNKVFVFFDLTVDDQSVYP |
| G.NGTFVNRELVGKGRRLPLSNNSEIALSVWSNKVFVFFDLTVDDQSVYP |
| G.NGTFVNRELVGKGRRLPLNNNCEIALSVWNNKVFVFFDLTVDDQSVYP |
| G.NGTFVNRELVGKEKRLPLSNNCEIALSVPTNKVFVFFDLTVDDQSIYP |
| G.NGTFVNKECVGKGKRLVLSNNSEIALSLLTNKVFVFFDLTVDDQSIYP |
| A.NGTFINRELIGKGKRLPLTHNSEIALSIQTNKVFVFSDLTVDDQLVFP |
| G.NGTFVNKEIIGKGRTLPLTNNAEIALSLPTNKVFVFSDLSVDDQTIYP |
| G.NGTWVDDEKLGNGKQSLLGNNSVIALAEQKHQVFMFIDKMADDQANLP |
| S.NGTFVNGEKIGKGKKQVLNNNDEIALSLSKNKAYVFMDTKDSDQSNLP |
| GQNGVYVNGVKIPSGRKQTIKTSDEIGIAYNNFNVFLFIDKEKDSDLEVS |
| R.NGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIGLP |
| |
| KALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSARE |
| KELRDEYIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSRE |
| KELRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSERE |
| KELRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSERE |
| KELRDQYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSARE |
| SELREKYIMSKTLGSGACGEVKLAFERKTCKKVAVKIISKRKFSICATRE |
| SEFREKYIMYKTLGSGACGEVKLAFEKTTCKKVAVKIISKRKFSFCSVRE |
| REFREKYIMSKTLGSGACGEVKLAFEKSTCNKVAVKIINKRKFMASGGRE |
| KDFIDKYIMSRPIGSGACGEVKLAFQKSVCKKVAVKIISKRKFKMNTSSN |
| LEFSKKYHIARKIGTGVCGEVKLAIEKETFKKVALKTINKHDFP....SI |
| EALREKFIMSKVLGRGACGQVKLAFEKGTCRKVAVKIIEKKTFSIGGTMV |
| DEFSKKYITHKLLGKGACGQVWEVWERFCAGKFAVKIISKTYLSVS.... |
| EEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPST |
| |
| A.DPALNVETEIEILKKLNHPCIIKIKNFFDAED.YYIVLELMEGGELFD |
| A.DTAPSVETEIEILKKLNHPCIIKIKDVFDAED.YYIVLELMEGGELFD |
| A.DPALDVETEIEILKKLNHPCIIKIKDFFDAED.YYIVLELMEGGELFD |
| A.DPALDVETEIEILKKLNHPCIIKIKDFFDAED.YYIVLELMEGGELFD |
| A.DPALNVETEIEILKKLNHPCIIKIKNFFDAED.YYIVLELMEGGELFD |
| A.DPAFNVETEIEILKKLNHPCIIKIKNFFDAED.YFIVLELMEGGELFE |
| A.DPAQSVETEIEILKKLNHPCIVKIKNFFEAED.YFIVLELMEGGELFD |
| A.NPAFNINTEIEILKKIDHPCLIKIKNFFEAED.YYIVLELMEGGELYD |
| E.HP.ISVDTEIEILKKLDHPCIIKIENFFDSEDFYYIVLELMEGGELFD |
| G.TATRNAEREIEILKKIDHPCLIKTEDFYQTEDSYYIVLEYIEGGELFG |
| R.NMEKTVMEEVRILKRLHHPCIIGIEDVCDTPEVLYIVLELVESGELFD |
| ..PSSKDVIKEADILRKLSHPCIIGVHDVVDLPQNLYIVLEFAKGGELFK |
| NFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLN |
| |
| KVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEED |
| RVVGNKRLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEED |
| RVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQKED |
| RVVGHKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSPKED |
| RVVGNRRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQKED |
| RVVGNKRLNEATCKLYFYQMLLAVKYLHENGIIHRDLKPENVLLSSQQED |
| RVARKGGLKEATCKLYFYQMLLAVKYLHDNGIIHRDLKPENVLLSSHEEN |
| RVSRPVKMKEATCKLYFYQMLLAVKYLHDNGIIHRDLKPENVLLSSSEET |
| RVVNSTRLREPIAKLYFYQMLLAVQYLHENGVIHRDLKPENVLLSSTSEE |
| RIKAKKKLEEDIAKLYFYQMLKAVEYLHNNGIIHRDLKPENVLLASHDDI |
| RVVSLGKFDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSDDKE |
| RLERGGKLPEKIAKLYFFQMLSAVKYLHDNEITHRDLKPENILLMSTEEP |
| RIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEE |
| |
| CLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS.VGTA.GYNRAVD |
| CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVS.NGTA.GYSRAVD |
| CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNS.FGTA.GYNRAVD |
| CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNS.FGTA.GYNRAVD |
| CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVS.FGTA.GYNRAVD |
| CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVVLS.MGSA.GYTRAVD |
| CLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNS.FGTA.GYKSSVD |
| CLIKITDFGQSKILGETSLMKTLCGTPTYLAPEVLNS.FGTA.GYSRAVD |
| CCIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNT.AGTT.GYSSAVD |
| CLIKITDFNQSKILEESSLMKTLCGTPTYVAPEVFTH.ASTV.GYTKAVD |
| TILKVTDFGLSKFVGEQSLMKTLCGTPTYLAPEILTS.MGMG.GYTKAVD |
| CLIKITDFGMSRLVEEKSLMKTLAGTPSYLAPEIIKQHMGLGKGYTKQVD |
| TLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLIT.GGRE.AYTKKVD |
| |
| CWSLGVILFICLSGYPPFSE.....HRTQ..VSLKDQITSGKYNFIPEVW |
| CWSLGVILFICLSGYPPFSE.....HKTQ..VSLKDQITSGKYNFIPEVW |
| CWSLGVILFICLSGYPPFSE.....HKTQ..VPLKDQITSGKFNFIPEVW |
| CWSLGVILFICLSGYPPFSE.....HKTQ..VSLKDQITSGKYNFIPEVW |
| CWSLGVILFICLSGYPPFSE.....HKTQ..VSLKDQITSGKYNFIPEVW |
| CWSLGVILFVCLSGYPPFSE.....HKTQ..VPLKDQIISGKYKLIPEVW |
| CWSLGVILFVCLGGYPPFAEPSIAKHKTQ..VPLKDQITSGTLNFIPKAW |
| CWSLGVILFVCLCGYPPFNE.....QNTQ..LSLKDQITRGEYTFISKEW |
| CWSLGVILFVCLCGYPPFSE.....QNSN..IPLKNQIAEGKYTYIAAAW |
| YWSLGVLLFICLGGYPPFNT.....ECTT..MSVREQIINGEYRFIPSQW |
| CWSIGVILYICLAGYPPFSD.....EIKA..MNLDEQIKRGYYSFPTKYW |
| LWSLGVILYVCLVAFPPFSA.....ELTETGQSIDEQILSANYSFQNQPW |
| IWSLGVVLFTCLSGTLPFSD.....EYGT..PAA.QQIKKGRFAYGHPSW |
| |
| AEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEE |
| TDVSEEALDLVKKLLVVDPKARLTTEEALNHPWLQDEYMKKKFQDLLVQE |
| AEVSEKALDLVKKLLMVDPKVRFTTEEALRHPWLQDEDMKRKFQNLLSEE |
| AEVSEKALDLVKKLLIVDPKARFTTEEALRHPWLQDEDMKRKFNNLLSEE |
| AEVSEKALDLVKKLLVVDPKERFTTEDALRHPWLQDEDMKRKFEDLLLEE |
| KAVSDTALDLVKKLLVVDPKKRYTTEEALAHPWLQDEEMKSKFHALLMEE |
| AHVSEMAVDLVKKLLVVDPNERLTTEKALEHPWLQDESMKNTFERLLMQQ |
| KHVSNMALDLVKKLLVVDPSKRFTIEEALEHPWLQDEDMKNTFQQLLAQT |
| RNVSEQAFDLVKNLLVVDPEQRLTTKQALEHPWLQDDSMKHTVERLMYGV |
| KNVSNEAKDLVKKLLVVDPQKRLSVEEALEHPWLKDDRMRQNANQLMNPG |
| GSVSAPAIDMVKKLLTVDPKRRLTTKQALAHPWLQDQEVIDKAEKVMYPN |
| STVSNDAKNLVSSLLVLNANDRLTTSAAVAHPWLQDSEMIRTANSLMSTV |
| KSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQKAKRLMKLD |
| |
| NEST...................................ALPQVLAQPST |
| KNSV...................................TLPVAPAQTS. |
| KKST...................................ALLQVPAQPST |
| DKLM...................................AVTQVPAQPST |
| NKST...................................PVPQVPTQPST |
| TMPP...................................HLPPPPAQLST |
| KESI...................................ALPQHPIQPST |
| SATM...................................NPPQTSKMPVA |
| DHTM...................................PPP...IKKNI |
| AANQ...................................PMRPEA..... |
| RNGQ...................................MLP..PSAPVR |
| EIKPYQEFMGSHSASFDTRKISTDNDDSASDSSRPASLEMLPQTINLPSS |
| GMEI.............................................. |
| |
| SRKRPR.EGEAEGAETTKRPAVCAAVL |
| SQKRPL.ELEVEGMPSTKRLSVCGAVL |
| SRKRLL.EGEAEDADTTKRLAMCAAVS |
| SRKRLL.EGEAESADPTKRLAVCAAVS |
| SRKRPL.EGEVEDTDTPKRLAVCAAVS |
| SRKRPH.EGEEEDEASSSGHCLASTSLSTTQLPEKRERK |
| SRKRAW.EEEEEQPGTSKCS.VPCASFQTIQVLEKRQRK |
| TRKRLH.ENEDE.SVSSKRD.VPSTSLQKMR |
| IRKRGH.EWDQDASTSSCSEILPTSA.......EKRAKR |
| TRKRKAQEGEGEP..SSKRKPGP |
| SYYS.HF............MW |
| AEKRCHTPNSSAEEPTAKLSKC |
| .......EEENFLEPPTKRSRR |