Align GVGD

Align-GVGD is a freely available, web-based program that combines the biophysical characteristics of amino acids and protein multiple sequence alignments to predict where missense substitutions in genes of interest fall in a spectrum from enriched delterious to enriched neutral. Align-GVGD is an extension of the original Grantham difference to multiple sequence alignments and true simultaneous multiple comparisons.

!! IMPORTANT !!! Please make sure that all input files are in simple text format (i.e. use Notepad or Textedit)!


 
 Multiple sequence alignment in FASTA format:* 

 >sp|P04637|P53_HUMAN - Homo sapiens (Human).
 SVP-SQKT-YQGSYGFRLGFL
 >sp|P10360|P53_CHICKEN - Gallus gallus (Chicken).
 VVPSTEDYGGDFDFRVGFV

Please make sure that in your alignment '-' correspond to gaps and 'X' to unknown amino-acids because the results will be different.

(click here for more details)
  
 
Select your file to upload:  
 OR  
Paste your alignment:    
 OR  
Select one of our library alignments:
(click here for more details)
     
 
 
 Substitutions list:* 

 S96T
 S96P
 S96A

 (click here for more details) 		 
 
Select your file to upload:  
 OR  
Paste your list of substitutions:       
 
 E-mail (optional): 
 		  
   
 





18/09/2014
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